CAS 630-93-3 MFCD00069674-5,5-Diphenylhydantoin Sodium Salt 苯妥英钠 -LabNovo

5,5-Diphenylhydantoin Sodium Salt 苯妥英钠

CAS 630-93-3 MFCD00069674

化学结构图

SMILES: O=C1[N-]C(=O)C(c2ccccc2)(c2ccccc2)N1.[Na+]

化学属性

Mol. Formula	C15 H11 N2 O2 . Na
Mol. Weight	274.25
Stability	对湿度敏感
Appearance	白色粉末。易溶于水，溶于乙醇，几乎不溶于乙醚、氯仿。在空气中渐渐吸收二氧化碳而析出苯妥英。苯妥英熔点295-598℃，不溶于水，无臭，味苦。
Solubility	aqueous base: soluble

别名和识别编码

Chemical Name	5,5-Diphenylhydantoin Sodium Salt
Synonym	5,5-D 5,5-DIPHENYLHYDANTOIN SODIUM 5,5-Diphenyl Hydantoin Sodium {hazard_com} Dilantin Diphe Enkefal Epelin Eptoin OM-Hydantoine sodium PHENYLTOIN SODIUM Sodium 5,5-diphenylhydantoinate Sodium diphenyl hydantoinate Solantyl alepsin sodiu {} {hazard_com} Difhydan {} {} {hazard_com} Denyl sodium {} {} {} {Chemicalbook} DIPHENYLHYDANTO {} {} {} {} {ALD} 5,5-二苯基-2,4-咪唑烷二酮钠盐 {} {} {} {} {} {Chemicalbook} 5,5-二苯乙内酰脲钠 {} {} {} {} {} {} {JNK} 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin, 5,5-Diphenylhydantoin sodium salt {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {JNK} 5,5-D {} {} {} {} {} {} {} {} {Chemicalbook} 5,5-diphenylhydantoinsodiumsigmaultra {} {} {} {} {} {} {} {} {} {Chemicalbook} 5,5-diphenyl-2,4-imidazolidinedione monosodium salt {} {
CAS Number	630-93-3
PubChem Substance ID	657302
EC Number	211-148-2
MDL Number	MFCD00069674
Reaxys-RN	673467
Merck Number	7322
Chemical Name Translation	苯妥英钠
Wiswesser Line Notation	T5MVMV EHJ ER& ER &-NA-
Beilstein Registry Number	673467
LabNetwork Molecule ID	LN00239338
InChI	InChI=1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1

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产品应用

苯妥英钠抑制神经元的快灭活型（T型）Ca2+通道，抑制Ca2+内流。较大浓度时，苯妥英钠能抑制K+外流，延长动作电位时程和不应期。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes 6.1 Xn

Hazard statements

H302 Harmful if swallowed 吞食有害
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H317 May cause an allergic skin reaction 可能导致皮肤过敏

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSMU1400000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312+P330
P308+P313
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Warning {} {} {} {} {} {} {} {} {TCI}

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿

UN Number 2811 UN 2811 6.1/PG 3

Packing GroupIII

Hazard Class6.1(b)

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 12571 ug/kg/25M-C
TOXIC EFFECTS :
   Cardiac - pulse rate
   Cardiac - other changes
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volume(issue)/page/year: 6,255,1988

TYPE OF TEST            : LDLo - Lowest publi

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 647 mg/kg/21W-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 81,605,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4056540

TYPE OF TEST            : LDLo - L

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 153 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 14,253,1962

TYPE OF TEST            : LDLo - Lowest published letha

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 200 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 187,91,1987

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 141,183,1984

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 mg/L
REFERENCE :
   VIRLAX Virology.  (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
   V.1-    1955-  Volume(issue)/page/year: 99,257,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1300 mg/kg
SEX/DURATION            : female 17-22 day(s) after conception
                          lactating female 7 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 39,165,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 7-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   17,627,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOS

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES O

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 189 mg/kg
SEX/DURATION            : female 8-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   64,271,1982

Storage condition +4°C

其他信息

无臭，味苦；微有吸湿性；在空气中渐渐吸收二氧化碳，分解成苯妥英；水溶液呈碱性反应，常因部分水解而发生浑浊；溶于水和乙醇，不溶于氯仿或乙醚。
苯妥英钠价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 D1331 5,5-二苯基乙内酰脲钠盐 5,5-Diphenylhydantoin Sodium Salt 500G 2450元 2014/06/02 D1331 5,5-二苯基乙内酰脲钠盐 5,5-Diphenylhydantoin Sodium Salt 25G 403元
Sigma Aldrich:630-93-3(sigmaaldrich)
方法一:苯甲醛经缩合、氧化得到联苯甲酰，然后与尿素重排、环合得到苯妥英钠。将水、尿素及联苯甲酰依次加入反应锅，搅拌加热至98℃，加入30%氢氧化钠，回流1.5h。加水及适量少性炭脱色，冷至26-28℃，过滤，滤液用5%左右盐酸酸化至pH=5-6，温度45-55℃，过滤，用水洗涤，得苯妥英。将苯妥英投入碱液中加热溶解，用氢氧化钠溶液调节pH至11-11.5，加活万籁炭于75-80℃脱色半小时。压滤，冷至37-38℃，加入晶种放置结晶。冷至25℃过滤，结晶用蒸馏水洗涤，甩干，粉碎，于80℃左右干燥，得苯妥英钠。
图谱信息:苯妥英钠(630-93-3)红外图谱(IR2) 苯妥英钠(630-93-3)红外图谱(IR1)
用途一:抗癫痫药及抗心律失常药。对癫痫大发作疗效好，对精神运动性发作和局限性发作次之，对小发作不但无效，甚至能诱发。
MSDS 信息:5,5-Diphenylhydantoin sodium salt(630-93-3).msds
用途二:苯妥英钠抑制神经元的快灭活型（T型）Ca2+通道，抑制Ca2+内流。较大浓度时，苯妥英钠能抑制K+外流，延长动作电位时程和不应期。
上游原料:联苯甲酰
MOL 文件:630-93-3.mol
TCI Shanghai:苯妥英钠 5,5-Diphenylhydantoin Sodium Salt,>;98.0%(T)(630-93-3)

5,5-Diphenylhydantoin Sodium Salt 苯妥英钠

CAS 630-93-3 MFCD00069674

化学结构图

化学属性

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产品应用

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化学结构图

化学属性

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相关文献及参考

安全信息

其他信息

系列性分类

相关产品推荐

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