9H-Purine-6-thiol,2-amino-9-(2-deoxy-beta-D-erytho-pentofuranosyl)-,monohydrate

CAS 64039-27-6 MFCD01694188

化学结构图

64039-27-6
SMILES: O.NC1N=C(S)C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C=2N=1

化学属性

Mol. FormulaC10H13N5O3S.H2O
Mol. Weight301.36

别名和识别编码

Chemical Name9H-Purine-6-thiol,2-amino-9-(2-deoxy-beta-D-erytho-pentofuranosyl)-,monohydrate
Wiswesser Line NotationT56 BN DN FN HNJ GZ ISH D- BT5OTJ CQ DQ E1 &QH
Synonym Guanosine, 2'-deoxy-6-thio-, monohydrate beta-Deoxythioguanosine monohydrate beta-2'-Deoxy-6-thioguanosine monohydrate beta-TGdR monohydrate NSC-71261 beta-Thioguanine deoxyriboside monohydrate 9H-Purine-6-thiol, 2-amino-9-(2-deoxy-beta-D-ribofuranosyl)-, hydrate
CAS Number64039-27-6
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1092 mg/kg/1Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-57,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   33,3069,1973

RTECSUP0175000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 467 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Behavioral - tremor
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,522,1969

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 142 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Lungs, Thorax, or Respiration - other changes
   Endocrine - hyperglycemia
REFERENCE :
   CCYPBY Cancer Chemotherapy Reports, Part 3.  (Washington, DC)  V.1-6,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   4,41,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 354 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Behavioral - tremor
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,522,1969

系列性分类

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