4-Methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione 4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮

CAS 64224-21-1 MFCD00868499

化学结构图

64224-21-1
SMILES: CC1C(=S)SSC=1C1=CN=CC=N1

化学属性

Mol. FormulaC8H6N2S3
Mol. Weight226.34
TSCANo

别名和识别编码

Chemical Name4-Methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione
Synonym RP-35,972 5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione Oltipraz 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione BRN 0978110 CCRIS 4048 NSC 347901 RP 35972 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
MDL NumberMFCD00868499
EC Number264-736-6
CAS Number64224-21-1
Wiswesser Line NotationT6N DNJ B- ET5SSYJ CUS D1
Beilstein Registry Number0978110
Chemical Name Translation4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, O, 生物活性小分子, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Biology, O

相关文献及参考

  • [2]. Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234(2):73-87.
  • [3]. Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5.
  • [4]. Eba S, et al.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Am J Respir Cell Mol Biol. 2013 Aug;49(2):324-33.
  • [1]. Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effec
  • [1]. Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8(10):2791-802.

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
RTECSJP1293000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S37 Wear suitable gloves 戴适当手套；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition Light Sensitive 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37XLA2 "Current Chemotherapy, Proceedings of the 10th International Congress
   of Chemotherapy, Zurich, 1977," Siegenthaler, W., and R. Luethy, eds., 2
   vols., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 1,148,1978

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   5,359,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 43 mg/kg/D
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   5,359,1980

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   5,359,1980

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mg/L
REFERENCE :
   CBTOE2 Cell Biology and Toxicology.  (Princeton Scientific Pub., Inc., 301
   N. Harrison St., CN 5279, Princeton, NJ 08540)  V.1-    1984-
   Volume(issue)/page/year: 2,379,1986

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 mg/L
REFERENCE :
   CBTOE2 Cell Biology and Toxicology.  (Princeton Scientific Pub., Inc., 301
   N. Harrison St., CN 5279, Princeton, NJ 08540)  V.1-    1984-
   Volume(issue)/page/year: 2,379,1986

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. O - Bioactive Small Molecules
  1. Medical Research Areas
  2. Metabolism
  3. HIF/HIF Prolyl-Hydroxylase  (缺氧诱导因子/缺氧诱导因子脯氨酸羟化酶)

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