(S)-Scoulerine 金黄紫堇碱

CAS 6451-73-6 MFCD00221721

化学结构图

6451-73-6
SMILES: COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2

化学属性

Mol. FormulaC19 H21 N O4
Mol. Weight327.37
Density
Boiling Point
Melting Point>165°C (dec.)

别名和识别编码

Chemical NameScoulerine, 98%, from Lily
CAS Number6451-73-6
Synonym ######## (S)-Scoulerine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Chemical Name Translation金黄紫堇碱
Wiswesser Line NotationT D6 B666 KN&TT&J GO1 HQ PO1 QQ
InChIKeyKNWVMRVOBAFFMH-UHFFFAOYSA-N
PubChem Substance ID439654
InChIInChI=1S/C19H21NO4/c1-23-17-4-3-11-7-15-13-9-16(21)18(24-2)8-12(13)5-6-20(15)10-14(11)19(17)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
LabNetwork Molecule IDLN01295811
MDL NumberMFCD00221721
EC Number
Beilstein Registry Number
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • (S)-Scoulerine is an alkaloid found in the opium poppy. (S)-Scoulerine acts as an antagonist at the ?2-adrenoceptor, ?1D-adrenoceptor and 5-HT receptor.

相关文献及参考

  • Morishige, T., et al.: Eur. J. Biochem., 269, 5659 (2002),
  • [1]. Habartova K, et al. Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. Sci Rep. 2018;8(1):4829. Published 2018 Mar 19.

安全信息

RTECSDR9808600 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,26,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   MZUZA8 Meditsinskii Zhurnal Uzbekistana.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) No.1-    1957-  Volume(issue)/page/year: (6),39,1977

GHS Symbol
UN Number
Hazard Codes
Signal word
WGK Germany
Safety Statements
Risk Statements
Precautionary statements
Packing Group
Storage condition -20 -20°C -20℃

系列性分类

  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Microtubule/Tubulin  (微管/微管蛋白)

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