(5-Hydroxy-6-Methylpyridine-3,4-Diyl)Dimethanol 2-甲基-3-羟基-4,5-二羟甲基吡啶

CAS 65-23-6 MFCD00006335

化学结构图

65-23-6
SMILES: Cc1ncc(CO)c(CO)c1O

化学属性

Mol. FormulaC8H11NO3
Mol. Weight169.18
Melting Point214-215°C
Appearance 针状结晶(丙酮)。m.p.160℃ ,易升华,LD50(大鼠经口)4000mg/kg。
SolubilityH2O: 0.1 g/mL at 20 °C, clear, colorless
Boiling Point491.9°C at 760 mmHg

别名和识别编码

Chemical Name(5-Hydroxy-6-Methylpyridine-3,4-Diyl)Dimethanol
Synonym Pyridoxine {LY} Pyridoxine {} {LY} Pyridoxine {} {} {LY} Pyridoxine {} {} {} {LY} Pyridoxine {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00006335
CAS Number65-23-6
PubChem Substance ID24898690
EC Number200-603-0
Chemical Name Translation2-甲基-3-羟基-4,5-二羟甲基吡啶
Wiswesser Line NotationT6NJ B1 CQ D1Q E1Q
LabNetwork Molecule IDLN00196423
Canonical SMILESOCC1=C(CO)C(O)=C(C)N=C1
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分类

  • {SNA} Allium cepa (Onion), Hordeum vulgare (Barley), Phytochemicals by Plant (Food/Spice/Herb), Theobroma cacao (Chocolate), Vaccinium macrocarpon (Cranberry), Vitamin B, Vitamin B6, Vitamins, Zingiber officinale (Ginger), 生化试剂, 细胞生物学, 营养研究
  • {SNA} Allium cepa (Onion),

相关文献及参考

  • [1]. Li C, et al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSUV1300000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {}
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 139 mg/kg/5Y-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - paresthesis
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   311,986,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 4800 mg/kg/17W-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   309,445,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 43,116,1940

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3100 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 43,116,1940

其他信息

  • MSDS 信息:2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine(65-23-6).msds
  • 下游产品:磷酸吡哆醛
  • 上游原料:蔗糖
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量(g/kg) 最大允许残留量(g/kg) 维生素B6 运动营养食品 营养强化剂 0.2-10mg 维生素B6 果汁(味)型饮料 营养强化剂 0.4-1.6mg/kg(如为果汁(味)型固体饮料,则需按稀释倍数增加使用量) 维生素B6 较大婴儿和幼儿配方食品 营养强化剂 0.3-1.4 mg/100g 维生素B6 饼干 营养强化剂 0.23~0.47mg/100g
  • 方法一:存在于稻谷壳、甘蔗、酵母、麦芽等中。可从多种途径合成。
  • 用途一:调节皮脂腺活力,可用于脸部控油的清洁和护理产品。也可用于护发品,改善油性头发状况,健康毛囊
  • MOL 文件:65-23-6.mol
  • Sigma Aldrich:65-23-6(sigmaaldrich)
  • 海关编码:29362500
  • F:8-10
  • 用途二:本身为维生素,可作为食品添加剂。可也作吡硫醇盐酸盐的中间体。

系列性分类


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