2-[[N-(m-Hydroxyphenyl)-p-toluidino]methyl]-2-imidazoline mesylate 2-[N-(间羟基)-对甲苯胺甲基]-2-咪唑啉甲磺酸盐

CAS 65-28-1 MFCD00134201

化学结构图

65-28-1
SMILES: CS(=O)(=O)O.Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1

化学属性

Mol. FormulaC17H19N3O.CH4O3S
Mol. Weight377.46
Melting Point180-182
Solubilityethanol: soluble26 mg/mL H2O: soluble50 mg/mL
Appearance powder

别名和识别编码

Chemical Name2-[[N-(m-Hydroxyphenyl)-p-toluidino]methyl]-2-imidazoline mesylate
CAS Number65-28-1
Synonym 瑞支亭 PHENTOLAMINE MESILATE 酚妥拉明 甲磺酸盐 regitinmethanesulphonate Phentolamine mesylate VASOMAX REGITIN Regitine methanesulfonate Phentolamine methanesulfonate salt; 3-[N-(2-Imidazolin-2-ylmethyl)-p-toluidino]phenol methanesulphonate 2-(N-[M-HYDROXYPHENYL]-P-TOLUIDINOMETHYL)IMIDAZOLINE METHANESULFONATE SALT phentolaminemethanesulphonate PHENTOLAMINE MESYLATE 2-[N-(间羟基)-对甲苯胺甲基]-2-咪唑啉甲磺酸盐 酚胺唑啉马来酸盐
MDL NumberMFCD00134201
PubChem Substance ID135727347
EC Number200-604-6
Chemical Name Translation2-[N-(间羟基)-对甲苯胺甲基]-2-咪唑啉甲磺酸盐
Merck Number7264
Reaxys-RN3826682
Beilstein Registry Number3826682
Wiswesser Line NotationT5M CN BUTJ B1NR CQ&R D1 &WSQ1
LabNetwork Molecule IDLN00195558
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分类

  • {SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signal
  • {SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Fluorination Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Novartis, P-PH, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物

产品应用

  • α-肾上腺素受体拮抗剂;外周血管舒张剂。

相关文献及参考

  • Meier, R., et al.: Proc. Soc. Exp. Biol. Med., 71, 70 (1949),
  • Spergel, G., et al.: J. Am. Med. Assoc., 211, 266 (1970),

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P304+P340+P312
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P332+P313
  • P302+P352+P312+P362+P364
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P305+P351+P338+
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H302+H312+H332
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
RTECSSL5430000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xn,Xi
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
UN Number 3249
Storage condition 储存温度2-8℃
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,667,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNPHAG Journal de Pharmacologie.  (SPPIF, B.P.22, F-41353 Vineuil, France)
   V.1-    1970-  Volume(issue)/page/year: 5,101,1974

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,667,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,667,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Jap

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4 mg/kg
SEX/DURATION            : female 22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 76,415,1986

其他信息

  • RTECS号:SL5430000
  • MOL 文件:65-28-1.mol
  • 用途:主要用于心血管系统疾病、以及糖尿病、肾病、中毒性肠麻痹、急性呼吸窘迫综合症、毛细支气管炎、重症哮喘等。
  • color:white to off-white
  • PackingGroup:III
  • HazardClass:6.1(b)

系列性分类


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