Acetamide,2-((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-N-(2-hydroxyethyl)-

CAS 65089-17-0 MFCD00869091

化学结构图

65089-17-0
SMILES: CC1C(=CC=CC=1C)NC1C=C(Cl)N=C(N=1)SCC(=O)NCCO

化学属性

Mol. FormulaC16H19ClN4O2S
Mol. Weight366.90

别名和识别编码

Chemical NameAcetamide,2-((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-N-(2-hydroxyethyl)-
Wiswesser Line NotationT6M CN BHJ BS1VM2Q DG FMR B1 C1
Synonym Acetamide,
CAS Number65089-17-0
Beilstein Registry Number0845588
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 137 gm/kg/81W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 283,397,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17 gm/kg/81W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other transferases
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 283,397,1980

RTECSAB5860000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATHSBL Atherosclerosis (Shannon, Ireland).  (Elsevier Scientific Pub.
   Ireland Ltd., POB 85, Limerick, Ireland)  V.11-    1970-
   Volume(issue)/page/year: 30,45,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATHSBL Atherosclerosis (Shannon, Ireland).  (Elsevier Scientific Pub.
   Ireland Ltd., POB 85, Limerick, Ireland)  V.11-    1970-
   Volume(issue)/page/year: 30,45,1978

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 25 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,36,1980

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   24,147,1984

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