Ubenimex Hydrochloride 乌苯美司盐酸盐

CAS 65391-42-6 MFCD00058004

化学结构图

65391-42-6
SMILES: Cl.CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1C=CC=CC=1)C(O)=O

化学属性

Mol. FormulaC16H24N2O4·HCl
Mol. Weight344.84
Melting Point216-218°
TSCANo

别名和识别编码

Chemical NameUbenimex Hydrochloride
Synonym Bestatin hydrochloride Bestatin hydrochloride N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride
MDL NumberMFCD00058004
PubChem Substance ID253659625
Beilstein Registry Number4628066
CAS Number65391-42-6
Reaxys-RN5840390
Chemical Name Translation乌苯美司盐酸盐
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分类

  • {SNA} A to C,
  • A to C, Amino Acid Derivatives, Aminopeptidase, Aminopeptidase P, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, B, Bioactive Small Molecules, Biochemicals and Reagents, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, Core Bioreagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inhibits an Enzyme, L to O, Leucine Aminopeptidase, Leucine aminopeptidase, cytosol,

相关文献及参考

  • [2]. Qian X, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2016 May-Jun;23(3):e680-9.
  • [3]. Lis M, et al. The effects of bestatin on humoral response to sheep erythrocytes in non-treated and cyclophosphamide-immunocompromised mice. Immunopharmacol Immunotoxicol. 2013 Feb;35(1):133-8
  • [4]. Poloz Y, et al. Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum. Eukaryot Cell. 2012 Apr;11(4):545-57
  • 1. Jia, M.R., et al., The Analgesic Activity of Bestatin as a Potent APN Inhibitor Front. Neurosci. 4 , 50, (2010) 摘要
  • Gardiner, D.L., et al. J. Biol. Chem. 281 , 1741-1745, (2006) 摘要
  • Jia, M.R., et al., The Analgesic Activity of Bestatin as a Potent APN Inhibitor Front. Neurosci. 4 , 50, (2010) 摘要
  • Shin, Y.P., et al., Antimicrobial Activity Of A Halocidin-derived P

安全信息

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3
Storage condition -20°C

系列性分类


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