beta-D-Glucopyranuronic acid,1-deoxy-1-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-

CAS 66048-45-1 MFCD01725271

化学结构图

66048-45-1
SMILES: OC(=O)[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)N1C=C(F)C(=O)NC1=O

化学属性

Mol. FormulaC10H11FN2O8
Mol. Weight306.23

别名和识别编码

Chemical Namebeta-D-Glucopyranuronic acid,1-deoxy-1-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-
CAS Number66048-45-1
Synonym 5-Fluoro-1-(?-D-glucuronopyranosyl)uracil 1-Deoxy-1-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-?-D-glucopyranuronic Acid Acido
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Glucuronides
  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • 5-Fluorouracil N-?-D-Glucuronide is the N-glucuronide derivative of 5-Fluorouracil (F596010). 5-Fluorouracil N-?-D-Glucuronide unlike its O-glucuronide analog does not possess significant antitumor ac

相关文献及参考

  • Baba, T. et al.: Gann, 69, 283 (1978); Kaneko, M. et al.: Nucleic Acid Res., 3, 35 (1977);

安全信息

RTECSLZ6572600 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1883 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   118,721,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   69,283,1978

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物

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