Ethyl Bromodifluoroacetate 溴二氟乙酸乙酯

CAS 667-27-6 MFCD00042069

化学结构图

667-27-6
SMILES: CCOC(=O)C(F)(F)Br

化学属性

Mol. FormulaC4
Mol. Weight203
Boiling Point112
Refractive index1.3860 to 1.3890
Density1.583
Flash Point21°C(lit.)
TSCANo
Appearance 无色透明液体, 沸点112℃，密度1.583，折光率 n 20/D 1.387 。

别名和识别编码

Chemical NameEthyl Bromodifluoroacetate
CAS Number667-27-6
Alfabeta NameETHYLBROMODIFLUOROACETATE
MDL NumberMFCD00042069
PubChem Substance ID87564380
EC Number211-567-0
Beilstein Registry Number1906095
Reaxys-RN1906095
Synonym difluorobromo ethyl acetate Acetic acid, bromodifluoro-, ethyl ester Acetic acid, 2-bromo-2,2-difluoro-, ethyl ester Ethyl bromodifluoroacetate 98% 溴二氟乙酸乙酯 1-溴一二氟乙酸乙酯;溴二氟乙酸乙酯 二氟溴乙酸乙酯 BROMODIFLUOROACETIC ACID ETHYL ESTER ETHYL BROMODIFLUOROACETATE Ethyl 2,2-difluoro-2-bromoacetate Difluorobromoacetic acid ethyl ester
Chemical Name Translation溴二氟乙酸乙酯
InChIKeyIRSJDVYTJUCXRV-UHFFFAOYSA-N
LabNetwork Molecule IDLN00116599
InChIInChI=1S/C4H5BrF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3
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分类

  • {SNA} Alkyl Fluorinated Building Blocks, Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Esters, Fluorinated Building Blocks, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks
  • Alkyl Fluorinated Building Blocks, Building Blocks, C2

产品应用

  • Usually used in the preparation of substituted ethyl 2′-pyridyldifluoroacetates,4-alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines,α,α-difluoro-β-lactams,mono- and difluoromethylated phenanthridine derivatives.

相关文献及参考

  • Valuable building block for the introduction of the CF2 group by Reformatsky reaction with aldehydes. A further development of this chemistry involves the generation of an ɑɑ-difluoro-ß-lactone, followed by thermal decarboxylation as a high-yield route to 1,1-difluoroalkenes: J. Org. Chem., 60, 5378 (1995):

安全信息

Warnings IRRITANT, FLAMMABLE
GHS Symbol
WGK Germany3
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes C
Precautionary statements
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+
  • P301+P330+P331
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P304+P340
  • P405 Store locked up. 上锁保管。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P241+P242+P243
  • P301+P330+P331+P310
  • P403+P235
  • P305+P351+P338+P310
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
Signal word
UN Number UN2924 2924
Risk Statements
  • R10 Flammable 易燃
  • R34 Causes burns 会导致灼伤
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Packing GroupII
Hazard Class3/8
Storage condition Flammables area

其他信息

  • Hazard Note:Irritant/Flammable
  • Sigma Aldrich:667-27-6(sigmaaldrich)
  • 图谱信息:二氟溴乙酸乙酯(667-27-6)核磁图( 13 CNMR) 二氟溴乙酸乙酯(667-27-6)核磁图( 1 HNMR) 二氟溴乙酸乙酯(667-27-6)红外图谱(IR1) 二氟溴乙酸乙酯(667-27-6)质谱(MS)
  • Alfa Aesar:二氟溴乙酸乙酯,97% Ethyl bromodifluoroacetate, 97%(667-27-6)
  • MOL 文件:667-27-6.mol
  • Treatment of the Reformatsky reagent with aldehydes and ketones affords 2,2-difluoro-3-hydroxy esters. Please enquire for references and other data for this item.
  • MSDS 信息:Ethyl bromodifluoroacetate(667-27-6).msds
  • 二氟溴乙酸乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B1463 二氟溴乙酸乙酯 Ethyl Bromodifluoroacetate 25G 460元 2014/06/02 B1463 二氟溴乙酸乙酯 Ethyl Bromodifluoroacetate 250G 2450元 2014/06/02 B1463 二氟溴乙酸乙酯 Ethyl Bromodifluoroacetate 5G 235元
  • Acros Organics:溴二氟乙酸乙酯 Ethyl bromodifluoroacetate, 98%(667-27-6)
  • TCI Shanghai:二氟溴乙酸乙酯 Ethyl Bromodifluoroacetate,>;97.0%(GC)(667-27-6)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  6. C2 to C5 - Esters
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters
  6. C12 to C63

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