MRK560 MRK560

CAS 677772-84-8 MFCD77772848

化学结构图

677772-84-8
SMILES: O=S(=O)(N[C@H]1CC[C@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1)C(F)(F)F

化学属性

Mol. FormulaC19H17ClF5NO4S2
Mol. Weight517.92
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameMRK-560
Chemical Name TranslationMRK560
Chemicalbook IDCB02538282
FormulaC19H17ClF5NO4S2
Synonym MRK560; MRK 560; MRK-560
IUPAC NameN-((1r,4r)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide
InChIKeyWDZVWDXOIGQJIO-PPUGGXLSSA-N
InChIInChI=1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2/t14-,18-
Canonical SMILESO=S(C(F)(F)F)(N[C@H]1CC[C@](C2=CC(F)=CC=C2F)(S(=O)(C3=CC=C(Cl)C=C3)=O)CC1)=O
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产品应用

  • MRK-560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Protein Tyrosine Kinase
  3. Gamma-secretase

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