Nonactin 无活菌素
CAS 6833-84-7 MFCD00043039
化学结构图
SMILES: CC1CC2CCC(O2)C(C)C(=O)OC(C)CC2CCC(O2)C(C)C(=O)OC(C)CC2CCC(O2)C(C)C(=O)OC(C)CC2CCC(O2)C(C)C(=O)O1
化学属性
| Mol. Formula | C₄₀H₆₄O₁₂ |
|---|---|
| Mol. Weight | 736.93 |
| Solubility | Soluble in chloroform (9.80 - 10.20 mg/ml), ethanol (10 mM), DMSO (10 mg/ml), and methanol. Insoluble in water. |
| Stability | 对湿度敏感 |
| Melting Point | >103° C (dec.) |
| Boiling Point | |
| Flash Point | - |
别名和识别编码
| Chemical Name | Nonactin |
|---|---|
| Synonym | 3584-A 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl- 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, [1R-(1R*,2R*,5R*,7R*,10S*,11S*,14S*,16S*,19R*, 20R*,23R*,25R*,28S*,29S*,32S*,34S*)]- 5342 PFW 19 A 4426 A-5584 E-79-C N-329-A Nonactin Nonactin (Mixture contains Monactin and Dinactin) (Technical Grade) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} |
| MDL Number | - |
| CAS Number | 6833-84-7 |
| Chemical Name Translation | 无活菌素 |
| EC Number | 229-911-3 |
| Beilstein Registry Number | 76434 |
| PubChem Substance ID | 72519 |
| InChI | InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36- |
| LabNetwork Molecule ID | LN00372334 |
| Canonical SMILES | - |
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分类
- {SNA} Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antimycobacterial, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Interferes with Cell Membrane Permeability (Ionophores), Interferes with DNA Synthesis, Macrolides, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
- {SNA} Antibacterial, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antimycobacterial, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Inhibits an Enzyme, Interferes with Cell Membrane Permeability (Ionophores), Interferes with DNA Synthesis,
产品应用
- Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.
- Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN.
- Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.
- Nonactin is used in urea and ammonium specific electrodes.
相关文献及参考
- [2]. Shikata Y, et al. Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. Cancer Sci. 2017 Apr;108(4):772-784.
- [3]. Barazi HO, et al. Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 2002 Mar 1;62(5):1541-8.
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
- Short: III/5b Title: Structure Data of Organic Crystals: C 14 ... C 120 Author: Schudt, E.; Weitz, G. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/5b Year: 1971 ISBN: 3-540-05177-5 ISBN: 978-3-540-05177-0 Internet Resource: DOI:10.1007/b19970 RefComment: XXI, 736 pages, and VII, 890 pages. Hardcover
安全信息
GHS Symbol
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 246 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,393,1980
其他信息
- Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request
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