1-Amino-4-Methylpiperazine 1-氨基-4-甲基哌嗪

CAS 6928-85-4 MFCD00006154

化学结构图

6928-85-4
SMILES: CN1CCN(N)CC1

化学属性

Mol. FormulaC5H13N3
Mol. Weight115.18
Refractive index1.4820 to 1.4860
Boiling Point172-175 °C at 760 mmHg
Density0.957
Flash Point103°C(lit.)
TSCANo
Appearance 无色透明粘稠液体。
Solubilitymiscible

别名和识别编码

Chemical Name1-Amino-4-Methylpiperazine
CAS Number6928-85-4
PubChem Substance ID81349
EC Number230-053-7
MDL NumberMFCD00006154
Beilstein Registry Number103334
Synonym 4-Methylpiperazin-1-amine {LY} 4-Methylpiperazin-1-amine {} {LY} 4-Methylpiperazin-1-amine {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylpiperazin-1-amine {} {} {} {}
Chemical Name Translation1-氨基-4-甲基哌嗪
Reaxys-RN103334
LabNetwork Molecule IDLN00194308
InChIInChI=1S/C5H13N3/c1-7-2-4-8(6)5-3-7/h2-6H2,1H3
Canonical SMILESNN1CCN(C)CC1
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分类

  • {SNA} Building Blocks, C4 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines
  • Building Blocks, C4 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines

相关文献及参考

  • Beil. 23 ,IV,376
  • Corp MSDS 1 (1), 193:B / FT-IR 2 (1), 583:A / RegBook 1 (1), 393:K / Structure Index 1 , 56:C:7 / Vapor Phase 3 , 465:D

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xn Xi,Xn
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302+H312+H332
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupIII
UN Number UN2735 2733
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class3

其他信息

  • Alfa Aesar:1-氨基-4-甲基哌嗪,98% 1-Amino-4-methylpiperazine, 98%(6928-85-4)
  • 用途一:用作医药中间体，用于合成抗生素利福平
  • TCI Shanghai:1-氨基-4-甲基哌嗪 1-Amino-4-methylpiperazine,>;98.0%(T)(6928-85-4)
  • 海关编码:29335995
  • Acros Organics:1-氨基-4-甲基哌嗪 1-Amino-4-methylpiperazine, 99%(6928-85-4)
  • 图谱信息:1-氨基-4-甲基哌嗪(6928-85-4)核磁图( 13 CNMR) 1-氨基-4-甲基哌嗪(6928-85-4)红外图谱(IR1) 1-氨基-4-甲基哌嗪(6928-85-4)质谱(MS)
  • MOL 文件:6928-85-4.mol
  • Sigma Aldrich:6928-85-4(sigmaaldrich)
  • 敏感性:Air & Light Sensitive
  • MSDS 信息:1-Amino-4-methylpiperazine(6928-85-4).msds
  • 用途二:医药中间体，用于生产抗菌素利福平。
  • 上游原料:锌粉 --> Α-球蛋白 --> N-甲基哌嗪 --> 哌嗪(六水) --> 1-甲醛哌嗪
  • 方法一:以六水哌嗪为原料，经甲基化、水解、亚硝化，还原等步骤得到。（1）甲基化将六水哌嗪溶于甲酸中，吸入反应锅内，升温到90℃，搅拌下滴加甲醛约1h，加毕，于90-95℃保温反应1h，减压蒸去水及过量的原料，得甲基甲酰基哌嗪浓缩液。（2）水解将盐酸和水加到上述浓缩液中，搅拌升温至105℃，回流反应2h。减压蒸馏至无馏出液为止，弃去馏出的酸液，残留液冷至15℃，放置过夜，过滤，滤液即甲基哌嗪盐酸盐溶液。（3）亚硝化将水解步骤得到的滤液在30℃滴加亚硝酸钠溶液，加毕，保温反应30min，得甲基硝基哌嗪生成液。（4）还原在亚硝化生成液中加入冰醋酸，冷却，于30-40℃逐步加入锌粉，加毕，于30-40℃保温反应1.5h，冷至15℃左右，放置过夜，甩滤。将此还原滤液加至预先已配置液碱并冷至10℃以下的碱化锅中，充分冷却后送至萃取锅，分3次加入氯仿进行萃取，合并氯仿萃取液，进行常压蒸馏回收氯仿，至液温为85℃时转入精馏锅中，先常压蒸馏至液温为135℃，再进行减压蒸馏，收集120℃（5.33-8.0kPa）馏分即为1-氨基-4-甲基哌嗪。上述四个步骤的总收率约30%。原料消耗定额：六水哌嗪（95%）1148.1kg/t、甲酸（85%）2266.2kg/t、甲醛（37%）1130.8kg/t、锌粉（90%）1900.2kg/t、冰乙酸3759.4kg/t、浓盐酸4046.5kg/t、亚硝酸钠937.6kg/t。
  • 1-氨基-4-甲基哌嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A1192 1-氨基-4-甲基哌嗪 1-Amino-4-methylpiperazine 500ML 3430元 2014/06/02 A1192 1-氨基-4-甲基哌嗪 1-Amino-4-methylpiperazine 25ML 366元 2010/06/21 251391000 1-氨基-4-甲基哌嗪 1-Amino-4-methylpiperazine 99% 100 GR 1738元

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Oxazolines/Oxazolidines 恶唑啉/恶唑烷
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperazines 哌嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperazines 哌嗪
  5. C4 to C8 - Piperazines

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