Indol-3-methanol 吲哚-3-甲醇
CAS 700-06-1 MFCD00005632
化学结构图
SMILES: OCc1c[nH]c2ccccc12
化学属性
| Mol. Formula | C9H9NO |
|---|---|
| Mol. Weight | 147 |
| Density | 1.272 |
| Melting Point | 96-99 |
| TSCA | No |
别名和识别编码
| Chemical Name | Indol-3-methanol |
|---|---|
| CAS Number | 700-06-1 |
| Alfabeta Name | HYDROXYMETHYLINDOLE 3- |
| MDL Number | MFCD00005632 |
| Synonym | 3-Hydroxymethylindole 3-Indolemethanol (1H-Indol-3-yl)-methanol 3-Indolylcarbinol |
| EC Number | 211-836-2 |
| Beilstein Registry Number | 121323 |
| PubChem Substance ID | 3712 |
| Reaxys-RN | 121323 |
| Chemical Name Translation | 吲哚-3-甲醇 |
| Wiswesser Line Notation | T56 BMJ D1Q |
| LabNetwork Molecule ID | LN00173548 |
| InChI | InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2 |
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分类
- {SNA} Alkaloid, Antioxidant, Chemopreventive Agents, Functional Foods, Gene Regulation, Phytochemicals by Chemical Classification, 癌症研究, 细胞生物学, 营养研究
- {SNA} Alkaloid, Antioxidant, Cell Biology, Chemopreventive Agents, Functional Foods, Gene Regulation, Nutrition Research, Phytochemicals by Chemical Classification, 癌症研究
- {SNA} Alkaloid, Antioxidant, Functional Foods, Gene Regulation, Phytochemicals by Chemical Classification, 化学预防剂, 癌症研究, 细胞生物学,
产品应用
- 抑制癌变。已被证明抑制动物的癌变。发现于十字花科蔬菜中发现。
相关文献及参考
- [2]. Safa M, et al. Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells. Tumour Biol. 2015 May;36(5):3919-30.
- [3]. Lee YR, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 May 17;364(6441). pii: eaau0159.
- Bailey, G.S., et al.: J. Natl. Cancer Inst., 78, 931 (1987),
- On treatment with acids, is converted to a stabilized cation 3-methylene-3H-indolium, which can undergo further reaction to give diindol-3-ylmethane. Moody's group have demonstrated a formal [3+2] cycloaddition of the cation to a variety of alkenes to give cyclopenta[b]indoles: J. Chem. Soc., Perkin 1, 1127 (1995):
- Stresser, D.M., et al.: J. Biochem. Toxicol., 10, 191 (1995),
- [1]. Mohammadi S, et al. Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line.J Recept
安全信息
GHS Symbol
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Behavioral - coma REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 18,159,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 400 mg/kg SEX/DURATION : female 8-9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 18,159,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1 mg/kg SEX/DURATION : female 15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - delayed effects REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 141,68,1996
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