Morphinan-6-one,4,5-alpha-epoxy-3-hydroxy-17-methyl-, hydrochloride,(5'-alpha)- Hydromorphone
CAS 71-68-1 MFCD03427563
化学结构图
SMILES: CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@H]3[C@H]1C5.Cl
化学属性
| Mol. Formula | C17H19NO3.ClH |
|---|---|
| Mol. Weight | 321.83 |
别名和识别编码
| Chemical Name | Hydrochloride |
|---|---|
| CAS Number | 71-68-1 |
| Synonym | (5?)- Dilaudid 4,5-alpha-Epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride Hymorphan Laudicon Hydromorphone hydrochloride Dihydromorphinone hydrochloride Dilaudid hydrochloride |
| MDL Number | MFCD03427563 |
| PubChem Substance ID | 5462347 |
| EC Number | 200-762-6 |
| Wiswesser Line Notation | T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JQ P1 &GH |
| Chemical Name Translation | Hydromorphone |
| InChI | InChI=1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2,4,10-11,16,19H,3,5-8H2,1H3;1H/t10-,11+,16-,17-;/m0./s1 |
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分类
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Alkaloids, Alphabetic, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, Drugs of Abuse, Excitatory Amino Acids - Opiod Agonists, Forensic and Veterinary Standards, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, H, HU - HZ, Membrane Protein Biology Tools, Morphine, Neurobiology, Neuroscience, Opioid Agonists, Opioids, Pharmacologicals,
产品应用
- Analgesic (narcotic). Preparation by electrolytic reduction of Morphine.
相关文献及参考
- Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941),
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 3 mg/kg TOXIC EFFECTS : Behavioral - analgesia Lungs, Thorax, or Respiration - other changes REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 194,296,1940
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 51 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 3,238,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 55 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,334,1964
TYPE OF TEST
TYPE OF TEST : L
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2500 ug/kg TOXIC EFFECTS : Behavioral - analgesia Lungs, Thorax, or Respiration - other changes REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(iss
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - hamster DOSE : 21500 ug/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 123,705,1975
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - hamster DOSE : 44 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 123,705,1975
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