2-(Propylamino)-N-(O-Tolyl)Propanamide 2-(丙基氨基)-N-(邻甲苯基)丙酰胺

CAS 721-50-6 MFCD00048681

化学结构图

721-50-6
SMILES: CCCNC(C)C(=O)Nc1ccccc1C

化学属性

Mol. FormulaC13H20N2O
Mol. Weight220.32 g/mol
Appearance 针状结晶。熔点37-38℃，沸点159-162℃（0.133kPa），折光率（nD20）1.5299。其盐酸盐（[1786-81-8]）为白色结晶性粉末。熔点167-168℃。易溶于水和乙醇，略溶于氯仿。味酸涩苦，无臭。
SolubilityDMSO 44 mg/mL Water <1 mg/mL Ethanol 44 mg/mL

别名和识别编码

Chemical Name2-(Propylamino)-N-(O-Tolyl)Propanamide
MDL NumberMFCD00048681
Chemical Name Translation2-(丙基氨基)-N-(邻甲苯基)丙酰胺
Synonym 2-(Propylamino)-o-propionotoluidide 2-(propylamino)-N-o-tolylpropanamide 2-(propylamino)-o-propionotoluidid 2-Methyl-alpha-propylaminopropionanilide Astra 1512 Astra 1515 Citanest L 67 N-(2-Methylphenyl)-2-(propylamino)propanamide N-(2-甲基苯基)-2-丙胺-丙酰胺 PRILOCAINE PRILOCAINE BASE Prilocaine {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number721-50-6
EC Number211-957-0
Beilstein Registry Number2108498
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安全信息

Storage condition 储存温度-20°C
RTECSUG5760000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 59900 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   61,455,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 231 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   61,455,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 519 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   61,455,1965

其他信息

  • 上游原料:邻甲基苯胺 --> 正丙胺 --> 丙酰溴
  • 方法一:邻甲苯胺与α-溴丙酰溴缩合后再与丙胺进行丙胺化反应即得丙胺卡因。
  • Prilocaine 是一种氨基酰胺类的局部麻醉剂。
  • MOL 文件:721-50-6.mol
  • 用途一:局部麻醉药。该品药效比普鲁卡因好，局麻作用强度及速度与利多卡因相似，但作用时间较长，毒性较小，因代谢快，蓄积性也较小。适用于硬膜外麻醉、传导麻醉和浸润麻醉等。

系列性分类

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