3-Amino-1-methyl-5H-pyrido[4,3-b]indole Acetate
CAS 72254-58-1 MFCD72254581
化学结构图
SMILES: CC1=N[14C](N)=CC2NC3C=CC=CC=3C1=2.CC(O)=O
化学属性
| Mol. Weight | 257 |
|---|---|
| Mol. Formula | C14H15N3O2 |
别名和识别编码
| CAS Number | 72254-58-1 |
|---|---|
| Chemical Name | 5H-Pyrido(4,3-b)indole, 3-amino-1-methyl-, acetate |
| Synonym | 5H-Pyrido(4,3-b)indol-3-amine, 1-methyl-, monoacetate 1-Methyl-3-amino-5H-pyrido[4,3-b]indole Acetate 1-Methyl-5H-pyrido[4,3-b]indol-3-amine Trp-P-2 (acetate) Trp-P-2 Acetate Tryptophan p 2 Acetate 3-Amino-1-methyl-5H-pyrido(4,3-b)indole acetate |
| Chemical Name Translation | |
| MDL Number | MFCD00869701 |
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分类
- Amines
- Heterocycles
- Mutagenesis Research Chemicals
产品应用
- Carcinogen
相关文献及参考
- Ohgaki, H., et al.: Carcinogenesis, 5, 921 (1984),
- Mutation Research, 187, 99-103 (1987),
- Eisenbrand & Tang: Toxicology, 84, 1 (1993),
- Sugimura, T., et al.: Mutation Research, 290, 43 (1993),
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 14 gm/kg/89W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 213,346,1981
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3011 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors REFERENCE : JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 84,852,1993
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 50 ng/plate REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,505,1984
TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 30 mg/kg/48H (Intermittent) REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 389,3,1997
TYPE OF TEST : DNA damage ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 13 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 395,57,1997
TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - rat DOSE/DURATION : 50 mg/kg/5D (Continuous) REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 251,59,1991
TYPE OF TEST : Specific locus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 400 ppm REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 122,315,1983
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 200 ng/well REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V.
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