N,N’-Ethylenebis(Iodoacetamide) N,N’-乙撑双(碘乙酰胺)

CAS 7250-43-3 MFCD00728185

化学结构图

7250-43-3
SMILES: O=C(CI)NCCNC(=O)CI

化学属性

Mol. FormulaC6H10I2N2O2
Mol. Weight395.98

别名和识别编码

Chemical NameN,N’-Ethylenebis(Iodoacetamide)
CAS Number7250-43-3
Synonym N,N'-1,2-Ethanediylbis(2-iodoacetamide) N,N?-1,2-ethanediylbis(2-iodoacetamide) N,N'-Ethylenebis(2-iodoacetamide) S 35 N,N'-Ethylene-bis(iodoacetamide) Acetamide, N,N'-1,2-ethanediylbis(2-iodo- Ethylenediamine bis(iodoacetamide) Acetamide, N,N'-ethylenebis(2-iodo-
MDL NumberMFCD00728185
Chemical Name TranslationN,N’-乙撑双(碘乙酰胺)
InChIKeyRLFPCLMBTQOMLI-UHFFFAOYSA-N
Wiswesser Line NotationI1VM2MV1I
Beilstein Registry Number2444246
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分类

  • Aliphatics
  • Cross Linking Reagents

产品应用

  • Used as a probe for the conformational state of the tubulin molecule. It reacts specifically with the sulfhydryl groups in tubulin.

相关文献及参考

  • Luduena, R.F., et al.: Biochemistry, 20, 4437 (1981),
  • Sullivan, K.F.: Ann. Rev. Cell Biology, 4, 687 (1988),

安全信息

RTECSAB8760000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   31,297,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Lungs, Thorax, or Respiration - pleural effusion
   Gastrointestinal - other changes
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   31,297,1963

系列性分类

  1. Haloalkyl
  2. alkyl iodide

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