Propiophenone, 2,4'-dimethyl-3-piperidino- 托哌酮

CAS 728-88-1 MFCD00242995

化学结构图

728-88-1
SMILES: Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1

化学属性

Mol. FormulaC16H23NO
Mol. Weight245.40

别名和识别编码

Chemical NamePropiophenone, 2,4'-dimethyl-3-piperidino-
EC Number211-976-4
Synonym 1-piperidino-2-methyl-3-(p-tolyl)-3-propanone 2-Methyl-3-piperidino-1-p-tolylpropan-1-one 1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)- (9CI) Tolperisone (base and/or unspecified salts) dl-Tolperisone 桃卜里松 NSC 107321 托哌酮 甲苯哌丙酮 Tolperisone Mideton Mydetone 2,4’-dimethyl-3-piperidino-propiophenon 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone TOLPERISONE Propiophenone, 2,4'-dimethyl-3-piperidino- (7CI, 8CI) 脑脉宁 Mydeton 2-Methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone AKOS 91983 托哌立松 2,4'-Dimethyl-3-piperidinopropiophenone 2-Methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone; 2,4'-Dimethyl-3-piperidinopropiophenone 托派松 2'4-Dimethyl-3-PiperidylPropiophenone 甲哌酮 mydeton 2-methyl-3-piperidino-1-p-tolylpropan-1-one α,4'-Dimethyl-β-piperidinopropiophenone
CAS Number728-88-1
MDL NumberMFCD00242995
Chemical Name Translation托哌酮
Wiswesser Line NotationT6NTJ A1Y1&VR D1
Beilstein Registry Number1285666
PubChem Substance ID5511
InChIInChI=1S/C16H23NO/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17/h6-9,14H,3-5,10-12H2,1-2H3
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安全信息

RTECSUH1575000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,257,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 645 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 5,421,1971

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TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1350 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 5,421,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/yea

其他信息

  • 用途一:中枢性肌松剂和血管扩张药。
  • Sigma Aldrich:728-88-1(sigmaaldrich)
  • MOL 文件:728-88-1.mol

系列性分类

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