CAS 7491-74-9 MFCD00079246-Piracetam 吡拉西坦 -LabNovo

Piracetam 吡拉西坦

CAS 7491-74-9 MFCD00079246

化学结构图

SMILES: NC(=O)CN1CCCC1=O

化学属性

Mol. Formula	C6H10N2O2
Mol. Weight	142.16
Appearance	白色结晶性粉末。熔点151.5-152.5℃。易溶于水，略溶于乙醇，几乎不溶于乙醚。无臭，味微苦。
Melting Point	151-152°C
Boiling Point	408.3°C at 760 mmHg
Flash Point	200.8°C

别名和识别编码

Chemical Name	Piracetam
CAS Number	7491-74-9
Synonym	Piracetam {LY} Piracetam Piracetam AbZ Piracetam RPh Piracetam-RPh Piracetrop Pirazetam Pyracetam Pyramem Sinapsan UCB 6215 UCB-6215 UCB6215 {} {LY} Piracetam {} {} {LY} Piracetam {} {} {} {LY} Piracetam {} {} {} {} {LY} Piracetam {} {} {} {} {} {LY} Piracetam {} {} {} {} {} {} {LY} Piracetam {} {} {} {} {} {} {} {LY} Piracetam {} {} {} {} {} {} {} {} {LY} Piracetam {} {} {} {} {} {} {} {} {} {LY} Piracetam {} {} {} {} {} {} {} {} {} {} {LY} Piracetam {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Piracetam {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Piracetam {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Piracetam {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Piracetam {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number	MFCD00079246
PubChem Substance ID	4843
EC Number	231-312-7
Chemical Name Translation	吡拉西坦
Wiswesser Line Notation	T5NVTJ A1VZ
Beilstein Registry Number	1526393
LabNetwork Molecule ID	LN00194990
InChI	InChI=1S/C6H10N2O2/c7-5(9)4-8-3-1-2-6(8)10/h1-4H2,(H2,7,9)
Canonical SMILES	O=C(N)CN1C(CCC1)=O

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产品应用

Nootropic.

安全信息

RTECSUX9660500

WGK Germany2

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

GHS Symbol

Safety Statements

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 23,795,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KHFZAN Khimiko-Farmatsevticheskii Zhurnal.  Chemical Pharmaceutical Journal.
    For English translation, see PCJOAU.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.1-    1967-  Volume(issue)/page/year: 11(8),132,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 47,205,1984

TYPE OF TEST

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
   V.8-43    1953-88 For publisher information, see FRMCE8
   Vol

Precautionary statements

Hazard statements

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

用途二:早期用材林于抗眩晕和止吐药，目前作为神经系统药物，有促进和增强大脑记乙功能的作用，对老年性记忆减退有效。对某些低智能儿的智力提高胶，对老年性痴呆、脑外伤引起的记忆和思维障碍亦有一定疗效。
下游产品:左乙拉西坦
中枢神经兴奋药:吡拉西坦又称脑复康、吡乙酰胺、乙酰胺吡咯环酮，是一种脑代谢改善药物，属于γ-氨基丁酸的环化衍生物，对中枢作用选择性强，仅限于脑功能(记忆、意识等)的改善，精神兴奋作用弱，无精神药物的副作用，无依赖性。可预防或保护动物因缺氧而导致的逆行性健忘，亦能明显拮抗巴比妥盐对中枢的抑制作用，能促进脑细胞代谢，增加大脑对氨基酸、蛋白质、葡萄糖的吸收和利用，具有激活、保护和修复大脑神经细胞的作用，能促使脑内ADP转化为ATP，改善脑内代谢能量供应状况。它影响胆碱能神经元兴奋传递，促进乙酰胆碱合成。吡拉西坦可以抵抗物理因素和化学因素所致的脑功能损害，改善学习、记忆和回忆能力。可以改善由缺氧所造成的逆行性遗忘。口服易吸收，30～40分钟后血药浓度达峰值，蛋白结合率为30%，清除半衰期4～6小时，易透过血脑屏障，到达脑和脑脊液。口服后不能由肝脏分解，以原形形式从尿和粪便中排泄。主要用于脑部疾病所致的记忆和思维障碍，儿童器质性痴呆和智力低下，对轻中度的老年性痴呆有一定的作用，但对重症者无效。对改善功能性大脑功能衰退症候群的症状也有一定的疗效。吡拉西坦也可用于脑炎、一氧化碳、农药及酒精中毒的意识恢复，可用静注或滴注。
MSDS 信息:Piracetam(7491-74-9).msds
MOL 文件:7491-74-9.mol
上游原料:甲醇钠 --> 氯乙酸乙酯 --> 氯乙酸甲酯 --> 2-吡咯烷酮
用途一:用于脑动脉硬化症及脑血管意外所致的记忆和思维功能减退的治疗
方法一:以2-吡咯烷酮为起始原料，在甲苯中与甲醇钠成盐，与氯代乙酸乙酯缩合后再氨化制得。
Sigma Aldrich:7491-74-9(sigmaaldrich)

Piracetam 吡拉西坦

CAS 7491-74-9 MFCD00079246

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