(1,3-Dioxo-4,5,6,7-Tetrahydro-1H-Isoindol-2(3H)-Yl)Methyl 2,2-Dimethyl-3-(2-Methylprop-1-En-1-Yl)Cyclopropanecarboxylate (1,3-二氧代-4,5,6,7-四氢-1H-异吲哚-2(3H)-基)甲基-2,2-二甲基-3-(2-甲基丙-1-烯-1-基)环丙烷甲酸酯

CAS 7696-12-0 MFCD00084635

化学结构图

7696-12-0
SMILES: CC(C)=CC1C(C(=O)OCN2C(=O)C3=C(CCCC3)C2=O)C1(C)C

化学属性

Mol. FormulaC19H25NO4
Mol. Weight331
Melting Point60-80 ºC
Flash Point200°C
Appearance 黄至琥珀色粘稠液体，溶于己烷、甲醇、二甲苯；不溶于水。对热稳定；光照下、与碱和某些乳化剂接触也能分解
Solubilityinsoluble
Density1.108

别名和识别编码

Chemical Name(1,3-Dioxo-4,5,6,7-Tetrahydro-1H-Isoindol-2(3H)-Yl)Methyl 2,2-Dimethyl-3-(2-Methylprop-1-En-1-Yl)Cyclopropanecarboxylate
MDL NumberMFCD00084635
PubChem Substance ID83975
Beilstein Registry Number8807938
CAS Number7696-12-0
EC Number231-711-6
Synonym 杀它死 阿斯 { NIA-9260 {Chemical D- 2,2-DIMETHYL-3-(2-METHYL-1-PROPENYL)CYCLOPROPANE 四甲菊酯 DURACIDE 1-cyclohexene-1,2-dicarboximidomethyl-2,2-dimethyl-3-(2-dimethyl-1-propenyl)cy 2,3,4,5-tetrahydrophthalimidomethylchrysanthemate (1,3,4,5,6,7-Hexahydro-1,3-dioxo-2H-isoindol-2-yl)methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate; (1-Cyclohexene-1,2-dicarboximido)methyl 2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylate 福马克拉 CYCLOHEX-1-ENE-1,2-DICARBOXIMIDOMETHYL-(1RS,3RS:1RS,3SR)-2,2-DIMETHYL-3(2-METHYLPROP-1-ENYL)CYCLOPROPANECARBOXYLATE 2,3,4,5-Tetrahydrophthalimidomethylchrysanthemate NEO-PYNAMIN(R) {Ch 2,2-二甲基-3-(2-甲基-1-丙烯基)环丙烷羧酸-3,4,5,6-四氢肽酰亚胺基甲基酯 3,4,5,6-TETRAHYDROPHTHALIMIDOMETHYL (1RS)-CIS-TRANS-CHRYSANTHEMATE 1-cyclohexene-1,2-dicarboximidomethy SP 1103 forte 3,4,5,6 CYCLOHEX-1-ENE-1,2-DICARBOXIMIDOMETHYL(1RS,3RS,1RS,3SR)-2,2-DIMETHYL-3-(2-METHYLPROP-1-ENYL)CYCLOPROPANECARBOXYLATE (1R)-2,2-Dimethyl-3α-(2-methyl-1-propenyl)cyclopropanecarboxylic acid (1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)methyl ester 3,4,5,6-Tetrahydrophthalimidomethyl cis and trans dl 3,4,5,6-TETRAHYDROPHTHAL-IMIDOMETHYL CHRYSANTHEMATE Neopinamin (1,3,4,5,6,7-Hexahydro-1,3-dioxo-2H-isoindol-2-yl)methyl (1R-tra 四甲司林 反-菊酸酯 3,4,5,6,7-2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylicacid(1 3，4，5，6-四氢酞 (+ 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylicacidesterwithn-(hydr Insectol (1,3,4,5,6,7-六氢-1,3-二氧代-2H-异吲哚-2-基)甲基-2,2- 胺菊酯 FMC-9260 {h
Chemical Name Translation(1,3-二氧代-4,5,6,7-四氢-1H-异吲哚-2(3H)-基)甲基-2,2-二甲基-3-(2-甲基丙-1-烯-1-基)环丙烷甲酸酯
Merck Number13,9296
Wiswesser Line NotationT56 BVNV&TJ C1OV- AL3TJ B1 B1 C1UY1&1
InChIInChI=1S/C19H25NO4/c1-11(2)9-14-15(19(14,3)4)18(23)24-10-20-16(21)12-7-5-6-8-13(12)17(20)22/h9,14-15H,5-8,10H2,1-4H3
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分类

  • {Chemicalbook} 农药: 杀虫（螨）剂: 拟除虫菊酯杀虫剂
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, Insecticides, Pesticides & Metabolites, Pesticides Standards, Phthalimides, Pyrethroids, T, TA - TE
  • Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, Insecticides, Pesticides, Pesticides & Metabolites, Phthalimides, Pyrethroids, Q-Z, T, TA -

相关文献及参考

  • Merck 14 ,9223

安全信息

RTECSGZ1730000
GHS Symbol
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
WGK Germany2
Personal Protective Equipment Gloves
Signal word Warning
Hazard Codes Xn N
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R50/53
  • R20 Harmful by inhalation 吸入有害
UN Number UN 2588 2588
Packing GroupIII
Hazard Class9
Storage condition 0-6°C 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 36,533,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2500 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - excitement
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 49(4),90,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,807,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 548 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 24,179,1982

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 50 mg/L
REFERENCE :
   ZYDXDM Zhejiang Yike Daxue Xuebao.  Journal of Zhejiang Medical University.
   (Zhejiang Yike Daxue, Yan'an Lu, Hanzhou, Zhejiang, Peop. Rep. China)  V.1-
   1972(?)-  Volume(issue)/page/year: 14,1,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 mg/L
REFERENCE :
   ZYDXDM Zhejiang Yike Daxue Xuebao.  Journal of Zhejiang Medical University.
   (Zhejiang Yike Daxue, Yan'an Lu, Hanzhou, Zhejiang, Peop. Rep. China)  V.1-
   1972(?)-  Volume(issue)/page/year: 14,1,1985

其他信息

  • 毒性:大鼠急性经口LD 50 为5200mg/kg，雄小鼠1920mg/kg，雌小鼠2000mg/kg；大鼠急性
  • 毒性分级:中毒
  • 注意事项:使用时勿直接喷到食品上。产品要包装在密闭容器中，贮于低温和干燥场所
  • 用途一:富右旋胺菊酯是我公司主产品之一，产品性状与 右旋胺菊酯相同，是世界卫生组织推荐用于公共卫生的主要杀虫剂之一。富右旋胺菊酯对蚊、蝇等卫生昆虫具有卓越的击倒力，对蟑螂有较强的驱赶作用，可将栖居在黑暗裂隙处的蟑螂赶跑出来，但致死性能差，有复苏现象，故常与其它杀死力高的药剂复配使用。加工成气雾剂或喷射剂，以防治家庭和畜舍的蚊、蝇和蟑螂等。还可以防治庭园害虫和食品仓库害虫。
  • 灭火剂:干粉、泡沫、砂土
  • 用途一:属卫生用低毒杀虫剂，对蚊、蝇、蟑螂等卫生害虫击倒速度快
  • 方法一:胺醇的合成 将1，2，4，6-四氢化邻苯二甲酸杆和五氧化二磷混合在反应器中，反应温度200℃，反应结束减压蒸馏得3,4,5,6-四氢化邻苯二甲酸酐。然后将其与尿素反应，得3，4，5，6-四氢化邻苯二甲酰亚胺。将亚胺、37%甲醛溶液、1%氢氧化钠溶液混合，以二氯乙烷为溶剂，加热回流，冷却后分出有机层，水层用二氯乙烷萃取，萃取液登工有机层，并用水洗涤，减压蒸馏得粗胺醇。粗胺醇加甲苯溶解，冷却至室温使之结晶，过滤、干燥得结晶状胺醇。 菊酰氯的制备 将菊酸乙酯、液碱、乙醇在加热条件下回流皂化，pH>;9，常压蒸出乙醇，加适量水，使菊酸钠溶解，再滴加10%盐酸，边搅拌加酸化，至水层pH≤2，分出有机层，水层用甲苯萃取，合并有机层，再水洗一次，蒸出甲苯得粗菊酸。将菊酸、三氯化磷和甲苯于50℃反应4h，分出亚磷酸，有机层减压脱溶，得粗菊酰氯。进一步减压蒸馏，收集96～98℃/2kPa馏分，得精菊酰氯。 胺菊酯的合成 加入胺醇、吡啶和甲苯，开动搅拌，微微加热，使胺醇全部溶解，冷却后，滴加菊酰氯甲苯溶液，滴毕于50～60℃反应2h。反应毕过滤，甲苯洗涤滤饼，合并滤液和洗涤液，用酸洗、碱洗、水洗至中性，减压脱溶，得胺菊酯原油，含量92%～93℃，收率92%以上。
  • Sigma Aldrich:7696-12-0(sigmaaldrich)
  • MSDS 信息:胺菊酯(7696-12-0).msds
  • 外观性质:纯品为白色结晶,原药为黄色膏状物或固体。
  • 上游原料:尿素 --> 甲醛 --> 三氯化磷 --> 氯乙烷 --> 甘氨酸乙酯盐酸盐 --> 菊酸 --> 邻苯二甲酸 --> 菊酸乙酯 --> 菊酰氯 --> 1,6-己二醇 --> 3,4,5,6-四氢苯酐 --> 四氢化邻苯二甲酸酐 --> 1,2
  • 毒性:大鼠急性经口LD 50 为5200mg/kg，雄小鼠1920mg/kg，雌小鼠2000mg/kg；大鼠急性经皮LD 50 >5000mg/kg。对皮肤和眼睛无刺激作用。以2000mg/kg剂量饲养大鼠3个月无影响。动物试验未见致癌、致突变作用。鲤鱼LC 50 为0.18mg/L
  • 中毒症状:属神经毒剂，接触部位皮肤感到刺痛，但无红斑，尤其在口、鼻周围。很少引起全身性中毒。接触量大时也会引起头痛，头昏，恶心呕吐，双手颤抖，重者抽搐或惊厥、昏迷、休克。
  • 刺激数据:眼睛-兔子 100 毫克/ 1小时 轻度
  • MOL 文件:1166-46-7.mol
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 类别:农药
  • 下游产品:卫生杀虫剂
  • 用途二:用于防治蚊、蝇、蟑螂等卫生害虫，具有触杀作有用、很强的击倒作用，对蜚蠊有驱赶作用，致死效果尚欠。与其他对人畜安全的卫生杀虫剂混配，制所气雾剂全用。
  • MOL 文件:7696-12-0.mol
  • 急救治疗:[1]无特殊解毒剂，可对症治疗。[2]大量吞服时可洗胃。[3]不能催吐 。
  • 急性毒性:口服- 大鼠 LD50: 4640 毫克 / 公斤; 口服- 小鼠 LD50: 1000 毫克/ 公斤
  • 可燃性危险特性:燃烧产生有毒的氮氧化物气体

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Alpha sort - Pesticides & Metabolites
  7. Q-Z - Alpha sort
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Pesticides - Pesticides & Metabolites
  7. Insecticides - Pesticides
  8. Pyrethroids - Insecticides
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. T - Alphabetic
  5. TA - TE - T
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. T - Alphabetic
  5. TA - TE - T

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