3-Ethyl-3-Methylpyrrolidine-2,5-Dione 3-乙基-3-甲基吡咯烷-2,5-二酮

CAS 77-67-8 MFCD00072123

化学结构图

77-67-8
SMILES: CCC1(C)CC(=O)NC1=O

化学属性

Mol. FormulaC7H11NO2
Mol. Weight141
Boiling Point150°C/12mmHg(lit.)
Melting Point48.0 to 52.0 deg-C

别名和识别编码

Chemical Name3-Ethyl-3-Methylpyrrolidine-2,5-Dione
CAS Number77-67-8
Synonym 2-Ethyl-2-methylsuccinimide 3-Ethyl-3-methyl- 3-Ethyl-3-methyl-2,5-pyrrolidine-dione 3-Ethyl-3-methylpyrrolidine-2,5-dione 3-Methyl-3-ethylpyrrolidine-2,5-dione Aethosuximide Asamid Atysmal CI 366 Capitus Emeside Epileo Petit MAL Ethosuccimid Ethosuccimide Ethosuccinimide Ethosuxide Ethosuximide Ethylmethylsuccimide Ethymal Etomal Etosuximida Etosuximida Faes Faes, Etosuximida H 940 Mesentol PM 671 Pemal Pemalin Pentinimid Petinimid Petnidan Pyknolepsinum Ronton Simatin(E) Succimal Succimitin Suksilep {hazard_com
MDL NumberMFCD00072123
PubChem Substance ID3291
EC Number201-048-7
Reaxys-RN117054
Beilstein Registry Number21(5)9,595
Merck Number3748
Chemical Name Translation3-乙基-3-甲基吡咯烷-2,5-二酮
Wiswesser Line NotationT5VMVTJ D2 D1
LabNetwork Molecule IDLN01309260
InChIInChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
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分类

  • Bases & Related Reagents
  • {SNA} Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, E, Neurobiology, Neuroscience, Pfizer Compounds, Pharmacologicals, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Nucleotides
  • Heterocycles
  • {SNA} Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Signaling and Neuroscience, E, Neurobiology, Neuroscience, Pfizer Compounds, Pharmacologicals, 细胞生物学
  • {SNA} Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology

产品应用

  • Anticonvulsant.

相关文献及参考

  • Sato, S., et al.: Neurology, 32, 157 (1982),
  • Wallance, S.J., et al.: Neurol. Clin., 4, 601 (1986),

安全信息

WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSWN2800000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Storage condition 0-10 0-10°C 储存温度2-8°C
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312
  • P301+P312+P330
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 780 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   NEPHBW Neuropharmacology.  (Pergamon Press Ltd., Headington Hill Hall,
   Oxford OX3 OBW, UK) V.9-    1970-  Volume(issue)/page/year: 24,427,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1810 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,117,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1325 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4188398

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1530 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   EPILAK Epilepsia (New York).  (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1-    1959-
   Volume(issue)/page/year: 4(4),66,1963

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 30 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 204,623,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 33300 ug/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
   In New Drugs, Proceedings of the Symposium on Toxicological Testing for
   Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
   Czechoslovakia, Univerzita Karlova, 1979  Volume(issue)/page/year: -,59,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 66600 ug/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
   In New Drugs, Proceedings of the Symposium on Toxicological Testing for
   Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
   Czechoslovakia, Univerzita Karlova, 1979  Volume(issue)/page/year: -,59,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 185 mg/kg
SEX/DURATION            : female 6-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   40YJAX "Evaluati

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurobiology - Neuroscience
  6. Pharmacologicals - Neurobiology
  7. Anticonvulsants - Pharmacologicals

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