Quinuclidin-3-Yl Acetate 1-氮杂双环环[2.2.2]-3-乙酸辛酯

CAS 827-61-2 MFCD00468105

化学结构图

827-61-2
SMILES: CC(=O)OC1CN2CCC1CC2

化学属性

Mol. FormulaC9H15NO2
Mol. Weight169.25

别名和识别编码

Chemical NameQuinuclidin-3-Yl Acetate
EC Number212-574-1
Synonym 3-Quinuclidinol acetate 1-Azabicyclo(2.2.2)octan-3-ol, acetate (3R)-1-Azabicyclo[2.2.2]oct-3-yl acetate 3-Acetoxyquinuclidine Aceclidine
CAS Number827-61-2
Wiswesser Line NotationT66 A B CNTJ AOV1
Chemical Name Translation1-氮杂双环环[2.2.2]-3-乙酸辛酯
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安全信息

RTECSVD6195000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,320,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 102 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,320,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 35,55,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 78 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - analgesia
   Nutritional and Gross Metabolic - body temperature decrease
REFEREN

系列性分类


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