N-(4-Methoxyphenyl)-N,2-Dimethylquinazolin-4-Amine (4-甲氧基苯基)(甲基)(2-甲基喹唑啉-4-基)胺

CAS 827031-83-4 MFCD27031834

化学结构图

827031-83-4
SMILES: COc1ccc(N(C)c2nc(C)nc3ccccc23)cc1

化学属性

Mol. FormulaC17H17N3O
Mol. Weight279.34
Appearance White solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameN-(4-Methoxyphenyl)-N,2-Dimethylquinazolin-4-Amine
Chemical Name Translation(4-甲氧基苯基)(甲基)(2-甲基喹唑啉-4-基)胺
Chemicalbook IDCB02574640
FormulaC17H17N3O
Synonym MPC6827; MPC-6827; MPC 6827; MX128495; MX-128495; MX 128495; EP90745; EP-90745;EP 90745; Verubulin; trade name: Azixa
IUPAC NameN-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine
InChIKeySNHCRNMVYDHVDT-UHFFFAOYSA-N
InChIInChI=1S/C17H17N3O/c1-12-18-16-7-5-4-6-15(16)17(19-12)20(2)13-8-10-14(21-3)11-9-13/h4-11H,1-3H3
Canonical SMILESCC1=NC(N(C2=CC=C(OC)C=C2)C)=C3C=CC=CC3=N1
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产品应用

  • Verubulin, also known as MPC-6827, is a quinazoline derivative with potential dual antineoplastic activities. Verubulin binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. MPC-6827 appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. VDA

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