STX-0119

CAS 851095-32-4 MFCD51095324

化学结构图

851095-32-4
SMILES: O=C(Nc1nnc(-c2ccco2)o1)c1cc(-c2ccccc2)nc2ccccc12

化学属性

Mol. Weight382.37
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation
Chemical NameSTX-0119
FormulaC22H14N4O3
Synonym STX0119; STX 0119; STX0119.
IUPAC NameN-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide
InChIKeyMNPXTRXFUMGQLK-UHFFFAOYSA-N
InChIInChI=1S/C22H14N4O3/c27-20(24-22-26-25-21(29-22)19-11-6-12-28-19)16-13-18(14-7-2-1-3-8-14)23-17-10-5-4-9-15(16)17/h1-13H,(H,24,26,27)
Canonical SMILESO=C(C1=CC(C2=CC=CC=C2)=NC3=CC=CC=C13)NC4=NN=C(C5=CC=CO5)O4
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产品应用

  • STX-0119 is a potent STAT3 inhibitor. STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors, and could be the next promising compound leading to survival prolongation. STX-0119 demonstrated strong inhibition of the expression of STAT3 target genes (c-myc, survivin, cyclin D1, HIF-1α and VEGF) and stem cell-associated genes (CD44, Nanog, nestin and CD133) as well as the induction of apoptosis in one stem-like cell line.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. HIF
  1. Medical Research Areas
  2. Epigenetics
  3. HIF

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