3-demethylthiocolchicine

CAS 87424-25-7 MFCD01671169

化学结构图

87424-25-7
SMILES: COc1c(O)cc2c(c1OC)-c1ccc(SC)c(=O)cc1[C@@H](NC(C)=O)CC2

化学属性

Mol. FormulaC21H23NO5S
Mol. Weight401.51

别名和识别编码

Chemical Name3-demethylthiocolchicine
CAS Number87424-25-7
Synonym Colchicine, O(sup 3)-demethyl-10-thio- 3-Desmethylthiocolchicine 2-Demethylthio-colchicine 3-Demethylthiocolchicine O(sup 3)-Demethyl-10-thiocolchicine 3-O-Demethylthi N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide
Beilstein Registry Number3176383
Chemical Name Translation
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分类

  • Glucuronide
  • Metabolites & Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • A Thiocolchicine metabolite, used in therapy as an antitunor, antiinflammatory and immunosuppressive agent.

相关文献及参考

  • Trellu, M., et al.: Fund. Clin. Pharmacol., 18, 493 (2004),
  • Nakagawa-Goto, K., et al.: Bioorg. Med. Chem. Lett., 15, 235 (2005),
  • Gelmi, M., et al.: J. Med. Chem., 50, 2245 (2007),

安全信息

RTECSAC8586000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 11300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 28,1204,1985

系列性分类

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