Diethylcarbamyl Chloride 二乙基氨基甲酰氯

CAS 88-10-8 MFCD00000636

化学结构图

88-10-8
SMILES: CCN(CC)C(=O)Cl

化学属性

Mol. FormulaC5H10ClNO
Mol. Weight135.59
Refractive index1.4480 to 1.4520
Boiling Point117-123
Density1.07
Melting Point-32
Flash Point76°C(lit.)
TSCAYes
Solubility水解
Appearance 浅黄色刺激性油状液体。
pH:A

别名和识别编码

Chemical NameDiethylcarbamyl Chloride
MDL NumberMFCD00000636
CAS Number88-10-8
Synonym Diethylcarbamic chloride {LY} Diethylcarbamic chloride {} {LY} Diethylcarbamic chloride {} {} {LY} Diethylcarbamic chloride {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {} {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {} {} {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {} {} {} {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethylcarbamic chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethylcarbamic chloride
PubChem Substance ID87567153
EC Number201-798-5
Beilstein Registry Number4,120
Reaxys-RN506687
Chemical Name Translation二乙基氨基甲酰氯
Wiswesser Line NotationGVN2&2
LabNetwork Molecule IDLN00225077
Canonical SMILESO=C(Cl)N(CC)CC
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分类

  • {uni_hamburg} no charge; carbonyl chloride; 1fragment
  • {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks

产品应用

  • 该品为医药、农药中间体,用于抗血丝虫药海群生、除草剂杀草丹等的生产。

相关文献及参考

  • Beilstein:4,120
  • Short: EINECS
  • Short: III/20a

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSFD4025000
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P308+P313
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P303+P361+P353
  • P403+P233
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P370+P378
  • P304+P340+P312
  • P305+P351+P338+P337+P313
  • P405 Store locked up. 上锁保管。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
Signal word
Packing GroupIII
UN Number UN3265
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Storage condition -20°C {LY} -20°C Moisture Sensitive {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Hazard Codes Xn
Hazard Class8
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 43200 mg/kg/72W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 6(4),479,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2700 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Gastrointestinal - alteration in gastric secretion
   Blood - changes in spleen
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0571246

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 159 ppm/7H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0571246

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 12840 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0571246

其他信息

  • Alfa Aesar:N,N-二乙基氯甲酰胺,98% Diethylcarbamyl chloride, 98%(88-10-8)
  • MOL 文件:88-10-8.mol
  • 用途二:该品为医药、农药中间体,用于抗血丝虫药海群生、除草剂杀草丹等的生产。
  • Sigma Aldrich:88-10-8(sigmaaldrich)
  • 用途一:用作医药及农药杀草丹的中间体
  • 方法一:以乙二胺为原料,与光气进行甲酰氯化反应,制得粗品二乙胺基甲酰氯,经脱酸而得成品。
  • 遇水极易分解,放出二乙胺和二氧化碳。
  • TCI Shanghai:二乙基氨甲酰氯 Diethylcarbamoyl Chloride,>;95.0%(GC)(88-10-8)
  • Acros Organics:N,N-二乙基氨基甲酰氯 Diethylcarbamyl chloride, 99%(88-10-8)
  • 图谱信息:N,N-二乙基氯甲酰胺(88-10-8)核磁图( 1 HNMR) N,N-二乙基氯甲酰胺(88-10-8)红外图谱(IR1) N,N-二乙基氯甲酰胺(88-10-8)核磁图( 13 CNMR) N,N-二乙基氯甲酰胺(88-10-8)质谱(MS)
  • 下游产品:1-二乙胺基甲酰基-4-甲基哌嗪 --> 1-二乙氨基甲酰基哌嗪
  • MSDS 信息:Diethylcarbamoyl chloride(88-10-8).msds
  • 上游原料:氯 --> 二乙胺 --> 冶金焦
  • N,N-二乙基氯甲酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D0482 二乙基氨甲酰氯 Diethylcarbamoyl Chloride 500G 879元 2014/06/02 D0482 二乙基氨甲酰氯 Diethylcarbamoyl Chloride 25G 166元 2010/06/21 114205000 N,N-二乙基氯甲酰胺 Diethylcarbamyl chloride 99% 500 ML 1116元
  • 敏感性:Moisture Sensitive

系列性分类


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