(1S,2S)-(+)-Pseudoephedrine (1S,2S)-(+)-2-甲氨基-1-苯基-1-丙醇

CAS 90-82-4 MFCD00064256

化学结构图

90-82-4
SMILES: CN[C@@H](C)[C@@H](O)c1ccccc1

化学属性

Mol. FormulaC10H15NO
Mol. Weight165.23
Melting Point118-120 °C

别名和识别编码

Chemical Name(1S,2S)-(+)-Pseudoephedrine
Synonym d-Pseudoephedrine (1S,2S)-PSEUDOEPHEDRINE, POLYMER-BOUND Pseudoephedrine (+)-PSEUDOEPHEDRINE, POLYMER-BOUND S,S-(+)-PSUEDOEPHEDRINE (+)-Pseudoephedrine (1S,2S)-2-methylamino-1-phenyl-propan-1-ol (+)-PSI-EPHEDRINE (+)-PSEUDOEPHEDRINE Benzenemethanol, α-[1-(methylamino)ethyl]-, [S-(R*,R*)]- ALPHA-(1-METHYLAMINOETHYL)BENZYL ALCOHOL, POLYMER-BOUND (1S,2S)-(+)-Pseudoephedrine {uni_hambu (+)-Pseudo-Ephedrin L(+)-ψ-Ephedrine S,S(+)-Pseudoephedrine PSEUDOEPHEDRINE ψ-Ephedrine, (+)- D-ISOEPHEDRINE trans-Ephedrine (1S,2S)-2-(METHYLAMINO)-1-PHENYLPROPAN-1-OL {uni d-ψ-Ephedrine 伪麻黄碱 L-(+)-Pseudoephedrine 假麻黃鹼 (+)-threo-Ephedrine D-PSEUDOEPHEDRINE (+)-pseudoephedrin d-Isoephedrine (+)-ψ-麻黄碱 (+)-伪麻黄碱 (1S,2S)-2-甲氨基-1-苯基-1-丙醇 d-伪麻黄碱 d-异麻黄碱 (+)-PSI-EPHEDRINE HYDROCHLORIDE, POLYMER-BOUND 2-甲胺基-1-苯基丙醇 Besan {uni_h (alpha-s)-benzenemethano psi-Ephedrine (+)-(1S,2S)-Pseudoephedrine (+)-psi-ephedrin (1S,2S)-2-甲氨基-1-苯基丙-1-醇 D-假麻黄碱 pseudoephedrine (INN) (1S,2S)-2-METHYLAMINO-1-PHENYL-1-PROPANOL (1S,2S)-2-METHYLAMINO-1-PHENYL-1-PROPANOL, POLYMER-BOUND (1S,2S)-(+)-PSEUDOEPHEDRINE, POLYMER-BOUND {Chemical (+)-METH ALPHA-(1-METHYLAMINOETHYL)BENZYL ALCOHOL (+)-Pseudoephedrine; (1S,2S)-2-Methylamino- 異麻黃鹼 Benzenemethanol, α-[(1S)-1-(methylamino)ethyl]-, (αS)-
MDL NumberMFCD00064256
PubChem Substance ID7028
Beilstein Registry Number2414132
EC Number202-018-6
CAS Number90-82-4
Chemical Name Translation(1S,2S)-(+)-2-甲氨基-1-苯基-1-丙醇
Merck Number13,8007
Wiswesser Line NotationQYR&Y1&M1
InChIInChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
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分类

  • {SNA} Alkaloid, Asymmetric Synthesis, Chemical Synthesis, Chiral Auxiliaries, Ephedra sinica, Ephedrine Derivatives, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb), 细胞生物学, 营养研究
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; alcohol; chiral; 1fragment
  • {SNA} Alkaloid, Asymmetric Synthesis, Chemical Synthesis, Chiral Auxiliaries, Ephedra sinica, Ephedrine Derivatives, Nutrition Research, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb)

相关文献及参考

  • Short: III/5a Title: Structure Data of Organic Crystals: C ... C 13 Author: Schudt, E.; Weitz, G. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/5a Year: 1971 ISBN: 3-540-05177-5 ISBN: 978-3-540-05177-0 Internet Resource: DOI:10.1007/b19970 RefComment: XXI, 736 pages, and VII, 890 pages. Hardcover Abstract: Volume III/5 offers a compitation as complete as possible of the space groups and lattice con-stants of all crystals which have been studied by means of X-rays, neutron and electron diffraction.
  • Short: IV/1a Title: Densities of Liquid Systems: Nonaqueous Systems and Ternary Aqueous Systems Author: Lacmann, R.; Synowietz, C. Editor: Schäfer, Kl. Source: Landolt-Börnstein, New Series Volume: IV/1a Year: 1974 ISBN: 3-540-06269-6 ISBN: 978-3-540-06269-1 Internet Resource: DOI:10.1007/b20003 RefComment: X, 716 pages. Hardcover Abstract: Volume IV/1 contains information on the densities of liquid systems. It may be considered as a supplement to volume II/1 of the 6th Edition, which contains only a few data on nonaqueous systems. Data are not listed for all systems but primarily for those of greater interest where data for a larger range of concentrations were available.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSUL5800000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Packing GroupIII
Hazard Class6.1(b)
UN Number 1544
Restrict 易制毒化学品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 88 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 148,158,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Skin and Appendages - sweating
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volu

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 85 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,225,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,225,1973

其他信息

  • 比旋光度:52 ° (c=0.6, EtOH)
  • 下游产品:麻黄碱 --> 甲基麻黄碱
  • Sigma Aldrich:90-82-4(sigmaaldrich)
  • MOL 文件:90-82-4.mol
  • MSDS 信息:Pseudoephedrine(90-82-4).msds

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Alkaloid - Phytochemicals by Chemical Classification

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