2-Chlorophenothiazine 2-氯吩噻嗪

CAS 92-39-7 MFCD00005016

化学结构图

92-39-7
SMILES: Clc1ccc2c(c1)Nc1ccccc1S2

化学属性

Mol. FormulaC12H8ClNS
Mol. Weight233.72
Melting Point195-200°C
TSCAYes
Density1.346
Appearance 浅黄色或银灰色结晶，熔点196-199℃（分解）。
Boiling Point395.7±31.0 °C at 760 mmHg

别名和识别编码

Chemical Name2-Chlorophenothiazine
CAS Number92-39-7
Synonym 2-Chlorophenothiazine {LY} 2-Chlorophenothiazine {} {LY} 2-Chlorophenothiazine {} {} {LY} 2-Chlorophenothiazine {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chlorophenothiazine {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00005016
PubChem Substance ID87565408
Beilstein Registry Number176587
EC Number202-152-5
Reaxys-RN176587
Alfabeta NameCHLOROPHENOTHIAZINE H210---
Chemical Name Translation2-氯吩噻嗪
Wiswesser Line NotationT C666 BM ISJ EG
LabNetwork Molecule IDLN00179331
Canonical SMILESClC(C=C1N2)=CC=C1SC3=C2C=CC=C3
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分类

  • Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Thiazines
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Thiazines
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards C - D,
  • {SNA} Analytical Standards, EP Standards, EP Standards C - D, Pharmacopeia Metrological Institutes Standards, 分析/色谱

产品应用

  • Metabolite of Chloropromazine

相关文献及参考

  • Motohashi, N., et al.: Anticancer Res., 17, 4403 (1997),
  • Beilstein: 27,IV,1290

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
RTECSSN7580000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Warnings IRRITANT
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
UN Number UN 2811 6.1/PG 3 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#00590

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 160 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   26,1205,1977

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 160 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   26,1205,1977

其他信息

  • 方法一:由间氯二苯胺经环合而得。在反应锅内加入间氯二苯胺和硫磺，升温至70℃，加入碘。升温至120℃，减压排出硫化氢，再升温至168-172℃，保温0.5h。冷却，加入氯苯和活性炭，加热回流1h。趁热过滤，滤液冷至15℃结晶。甩滤，用氯苯、乙醇洗涤滤饼各1次，得2-氯吩噻嗪。
  • 类别:有毒物质
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • 毒性分级:高毒
  • 用途二:医药中间体，用于制备氯丙嗪、奋乃静。
  • 2-氯吩噻嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0248 2-氯吩噻嗪 2-Chlorophenothiazine 500G 3010元 2014/06/02 C0248 2-氯吩噻嗪 2-Chlorophenothiazine 25G 352元 2010/06/21 334550250 2-氯吩噻嗪 2-Chlorophenothiazine 99% 25 GR 386元
  • MSDS 信息:2-Chlorophenothiazine(92-39-7).msds
  • 下游产品:盐酸氯丙嗪 --> 奋乃静
  • Acros Organics:2-氯吩噻嗪 2-Chlorophenothiazine, 99%(92-39-7)
  • 急性毒性:静脉- 小鼠 LD50: 18 毫克/公斤
  • 上游原料:氢硫酸 --> 间氯二苯胺
  • Sigma Aldrich:92-39-7(sigmaaldrich)
  • 储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
  • 用途一:用作药物盐酸氯丙嗪的中间体
  • TCI Shanghai:2-氯吩噻嗪 2-Chlorophenothiazine,>;98.0%(GC)(92-39-7)
  • 图谱信息:2-氯吩噻嗪(92-39-7)红外图谱(IR1) 2-氯吩噻嗪(92-39-7)质谱(MS) 2-氯吩噻嗪(92-39-7)核磁图( 13 CNMR) 2-氯吩噻嗪(92-39-7)红外图谱(IR2)
  • 可燃性危险特性:可燃, 燃烧时分解有毒氯化物, 硫氧化物和氮氧化物气体
  • MOL 文件:92-39-7.mol
  • Alfa Aesar:2-氯吩噻嗪,99% 2-Chlorophenothiazine, 99%(92-39-7)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Thiadiazoles 噻二唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Thiazines 噻嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Thiazines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Thiazines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Tetrazoles

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