N-(Hydroxymethyl)acrylamide N-(羟甲基)丙烯酰胺

CAS 924-42-5 MFCD00004597

化学结构图

924-42-5
SMILES: C=CC(=O)NCO

化学属性

Mol. FormulaC4H7NO2
Mol. Weight101.11
Refractive indexn20/D 1.413
Density1.074 g/mL at 25 °C
Melting Point75.0 to 79.0 deg-C
Solubility<0.1 G/100 ML AT 20.5 ºC
Stability对光敏感
Flash Point100°C
Boiling Point277°C(lit.)

别名和识别编码

Chemical NameN-(Hydroxymethyl)acrylamide
CAS Number924-42-5
PubChem Substance ID13543
Beilstein Registry Number506646
MDL NumberMFCD00004597
Reaxys-RN506646
EC Number213-103-2
Synonym N-MAN Monomethylolacrylamide N-羟甲基丙烯酰胺 N-Methylolacrylamide NM-AMD Methylolacrylamidesolution N-(Hydroxymethyl)acrylamide N-(羟甲基)丙烯酰胺 溶液 Acrylamide, N-(hydroxymethyl)- n-(hydroxymethyl)-2-propenamid N-Methyloacrylamide N-甲基戊烯聚合物 N-羥甲基丙烯醯胺 N-(Hydroxymethyl)-2-propenamide; N-(Hydroxymethyl)acrylamide N-METHYLOLACRYLAMIDE N-羟甲基-2-丙烯酰胺 N-(HYDROXYMETHYL)ACRYLAMIDE SOLUTION, ST AB., ~48% IN H2O N-Methanolacrylamide 2-Propenamide, N-(hydroxymethyl)- n-(hydroxymethyl)-2-propenamide Yuramin T 80 NCI-C60333 METHYLOLACRYLAMIDE
Chemical Name TranslationN-(羟甲基)丙烯酰胺
Wiswesser Line NotationQ1MV1U1
LabNetwork Molecule IDLN00222801
InChIInChI=1S/C4H7NO2/c1-2-4(7)5-3-6/h2,6H,1,3H2,(H,5,7)
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分类

  • {SNA} Acrylamide and Methacrylamide, Acrylic Monomers, Materials Science, Monomers, Polymer Science
  • Acrylamide and Methacrylamide, Acrylic Monomers, Materials Science, Monomers, Polymer Science
  • {SNA} Acrylamide and Methacrylamide, Acrylic Monomers, Monomers, Polymer Science, 材料科学

产品应用

  • 有机合成单体可用于制备多种共聚物。

相关文献及参考

  • Beil. 2 ,IV,1472
  • Aldrich MSDS 1 , 1065:D / Corp MSDS 1 (1), 1935:B / FT-IR 1 (1), 750:A / FT-IR 2 (1), 1270:C / RegBook 1 (1), 885:J / Sax 6 , 1578 / Structure Index 1 , 135:C:7

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H301 Toxic if swallowed 吞食有毒
  • H350 May cause cancer 可能致癌
  • H340 May cause genetic defects 可能导致遗传性缺陷
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes T Xn
Precautionary statements
  • P308+P311
  • P305+P351+P338
  • P308+P313
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P332+P313
  • P302+P352+P333+P313+P362+P364
  • P405 Store locked up. 上锁保管。
  • P301+P310
  • P305+P351+P338+P337+P313
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P301+P310+P330
Signal word
RTECSAS3600000
Storage condition 0-10 遇光、热易发生自聚，2-8℃保存 2-8℃保存 0-10°C Refrigerator
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R46 May cause inheritable genetic damage 可能引起遗传基因损害
  • R48/20/21/22
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R45 May cause cancer 可能致癌
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
UN Number 2810 2811 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25750 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-352,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 563 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   19,2591,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 474 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NEZAAQ Nippon Eiseigaku Zasshi.  Japanese Journal of Hygiene.  (Nippon Eisei
   Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606,
   Japan)  V.1-    1946-  Volume(issue)/page/year: 34,183,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 1,306,1978

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 16 gm/kg
TOXIC EFFECTS :
   Behavioral - tremor
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,111,1990

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 375 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-352,1989

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 250 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-352,1989

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 730 mg/kg/6W (Continuous)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   59,201,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4608 mg/kg
SEX/DURATION            : male 16 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   47,179,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 730 gm/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   59,201,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 730 gm/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   59,201,1986

Hazard Class6.1
Packing GroupIII

其他信息

  • N-羟甲基丙烯酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30201428 N-羟甲基丙烯酰胺 500g 44元 2011/04/16 M0574 N-(羟甲基)丙烯酰胺 N-(Hydroxymethyl)acrylamide 500G 526元 2011/04/16 M0574 N-(羟甲基)丙烯酰胺 N-(Hydroxymethyl)acrylamide 25G 195元
  • 外观性质:白色结晶粉末。
  • 用途三:有机合成单体可用于制备多种共聚物。
  • MSDS 信息:N-羟甲基丙烯酰胺(924-42-5).msds
  • 上游原料:甲醛 --> 丙烯腈 --> 丙烯酰胺
  • 用途一:可作交联剂，广泛用于纤维的改性树脂、加工染料、塑料粘合剂、土壤稳定剂等
  • 方法一:在弱碱性条件下，将丙烯酰胺与37%的甲醛水熔液反应而制得。
  • 用途二:该品分子中具有与羰基共轭的双键和富有反应性的羟甲基，是用途广泛的交联性单体，用于纤维的改性、树脂加工、粘合剂及纸张、皮革、金属表面的处理剂，还可用于土壤改良剂等。雄小鼠口服LD50为420mg/kg。
  • MOL 文件:924-42-5.mol
  • 下游产品:无纺布胶 --> 涂料印花粘合剂
  • Sigma Aldrich:924-42-5(sigmaaldrich)
  • 本品是一种自交型活性单体，在分子结构中，有与羟基共轭的双健又有活性的官能基，极易溶于水和醇中，难溶于氯仿及四氯化碳，在潮湿的空气中易于自聚交联成不溶性树脂，特别是在酸性条件下聚合更快。
  • TCI Shanghai:N-羟甲基丙烯酰胺 N-(Hydroxymethyl)acrylamide,>;98.0%(T)(924-42-5)

系列性分类

  1. Materials Science 材料科学
  2. Products for Polymer Science Research
  3. Monomers - Polymer Science
  4. Acrylic Monomers - Monomers
  5. Acrylamide and Methacrylamide - Acrylic Monomers
  1. Functional Group 官能团索引
  2. hemiaminal

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