2-(Trans-4-(4-Chlorophenyl)Cyclohexyl)-3-Hydroxynaphthalene-1,4-Dione 2-(反式-4-(4-氯苯基)环己基)-3-羟基萘-1,4-二酮
CAS 95233-18-4 MFCD09752107
化学结构图
SMILES: [2H]C1=C(Cl)C([2H])=C([2H])C([C@@H]2CC[C@H](CC2)C2=C(O)C(=O)C3C=CC=CC=3C2=O)=C1[2H] |&1:9,12|
化学属性
| Mol. Formula | C22H19ClO3 |
|---|---|
| Mol. Weight | 367 |
| Melting Point | 221 - 225 |
别名和识别编码
| Chemical Name | 2-(Trans-4-(4-Chlorophenyl)Cyclohexyl)-3-Hydroxynaphthalene-1,4-Dione |
|---|---|
| CAS Number | 95233-18-4 |
| Synonym | |
| Beilstein Registry Number | 8076827 |
| Chemical Name Translation | 2-(反式-4-(4-氯苯基)环己基)-3-羟基萘-1,4-二酮 |
| LabNetwork Molecule ID | LN01374900 |
| MDL Number | MFCD00889188 |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Antipneumocystic.
相关文献及参考
- [2]. Schöler N, et al. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.Antimicrob Agents Chemother. 2001 Jun;45(6):1771-9.
- El-Sadr, W.M., et al.: N. Engl. J. Med., 339, 1889 (1998),
- Fry, M., et al.: Biochem. Pharmacol., 43, 1545 (1992),
- Hudson, A.T., et al.: Drugs Exp. Clin. Res., 17, 427 (1991),
- [1]. Nilsen A, et al. Quinolone-3-diarylethers: a new class of antimalarial drug.Sci Transl Med. 2013 Mar 20;5(177):177ra37.
- [1]. Nilsen A, et al. Quinolone-3-diarylethers: a new class of antimalarial drug.Sci Transl Med. 2013 Mar 20;5(177):177ra37.
- [2]. Schöler N, et al. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.Antimicrob Agents Chemother. 2001 Jun;45(6):1771-9.
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