Styrene Oxide 氧化苯乙烯
CAS 96-09-3 MFCD00005121
化学结构图
SMILES: C1CCC(C2CO2)CC1
化学属性
| Mol. Formula | C8H8O |
|---|---|
| Mol. Weight | 120 |
| Refractive index | 1.5340 to 1.5360 |
| Boiling Point | 194 |
| Density | 1.054 |
| Melting Point | -37 |
| Flash Point | 77°C(lit.) |
| TSCA | Yes |
| Autoignition Point | 928 °F |
| Vapor Density | 4.14 (vs air) |
| Vapor Pressure | <;1 mmHg ( 20 °C) |
| Solubility | 3 G/L (20 ºC) |
别名和识别编码
| Chemical Name | Styrene Oxide |
|---|---|
| CAS Number | 96-09-3 |
| Synonym | 1,2-Epoxyethylbenzene, Phenylethylene oxide, Phenyloxirane ######## (1,2-Epoxyethyl)benzene (epoxyethyl)-benzen (±)-2-Phenyloxirane (±)-Styrene oxide 1,2-环氧乙基苯, 环氧苯乙烷 1-Phenyloxirane 2-PHENYLOXIRANE Ep Epoxyethylbenzene Epoxystyrene Ethane, 1,2-epoxy-1-phenyl- Fenyloxiran PHENYLETHYLENE OXIDE Phenyl oxirane Phenyloxirane <undefined optical isomer> STYRENE EPOXIDE Styrene 1',2'-oxide Styrene oxide benzene,(1,2-epoxyethyl) ep-182 {} {Chemical {} {} {Chemicalbook} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {Ch α,β-Epoxystyrene 氧化苯乙烯 氧化苯乙 |
| MDL Number | MFCD00005121 |
| Beilstein Registry Number | 108582 |
| PubChem Substance ID | 87569334 |
| EC Number | 202-476-7 |
| Reaxys-RN | 108582 |
| Chemical Name Translation | 氧化苯乙烯 |
| Wiswesser Line Notation | T3OTJ BR |
| LabNetwork Molecule ID | LN00193192 |
| InChI | InChI=1S/C8H8O/c1-2-4-7(5-3-1)8-6-9-8/h1-5,8H,6H2 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Epoxide Monomers, Monomers, Polymer Science, 材料科学
- {SNA} Alphabetical Listings, Flavors and Fragrances, Q-Z
- Heterocycles
- {uni_hamburg} no charge; oxygen heterocycle; carbocycle; aromatic; alicycle; 3ring; 6ring; ether; racemate; 1fragment
- {SA} Building Blocks, Chemical Synthesis, Epoxides, Organic Building Blocks, Oxygen Compounds
- {SNA} Epoxide Monomers, Materials Science,
产品应用
- 医药中间体。用于β-苯乙醇的中间体。
相关文献及参考
- Short: III/35D2
- Aryl substituted epoxides undergo rearrangement in the presence of NaBH4 in benzene to give arylacetaldehydes: Gazz. Chim. Ital., 121, 579 (1991).
- Beilstein:17,49
- In the presence of Pd(OAc)2 and Bu3P, a tandem isomerization-aldol condensation occurs: J. Org. Chem., 61, 7565 (1996):
- Shen, S. et al.: Drug Metab. Disp., 38, 1934 (2010); Carlson, G.P. et al.: J. Toxicol. Env. Health, 73, 1689 (2010)
- In the presence of excess of a second aldehyde, crossed aldol reactions occur in moderate yield.
安全信息
GHS Symbol
- H350 May cause cancer 可能致癌
- H319 Causes serious eye irritation 严重刺激眼睛
- H302 Harmful if swallowed 吞食有害
- H311 Toxic in contact with skin 皮肤接触中毒
- H315 Causes skin irritation 会刺激皮肤
- H331 Toxic if inhaled 吸入中毒
- H312 Harmful in contact with skin 皮肤接触有害
- H340 May cause genetic defects 可能导致遗传性缺陷
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H227 Combustible liquid 可燃液体
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312+P330
- P302+P350
- P302+P352+P312+P361+P364
- P304+P340
- P304+P340+P312
- P305+P351+P338
- P305+P351+P338+P337+P313
- P308+P313
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P337+P313
- P370+P378
- P403+P233
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
- R21 Harmful in contact with skin 与皮肤接触有害
- R36 Irritating to eyes 刺激眼睛
- R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R45 May cause cancer 可能致癌
- R46 May cause inheritable genetic damage 可能引起遗传基因损害
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 74 gm/kg/62W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 31,41,1963
TYPE OF
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 52 gm/kg/52W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors REFERENCE : MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925- Volume(issue)/page/year: 70,358,1979
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors REFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 77,471,1986
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 96 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease REFERENCE : RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued. Volume(issue)/page/year: 3,193,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB81-168510
TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSE
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 890 uL/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/21/1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 460 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,321,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 77,471,1986
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 70 ug/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,239,1987
TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 20 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,317,1
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 25 mg/L REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 8
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 300 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 231,205,1990
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 5 ug/well REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984
TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - hamster DOSE/DURATION : 500 mg/kg REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 26,305,1979
TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE : 100 ppm/7H SEX/DURATION : female 1-19 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975- Volume(issue)/page/year: 9,94,1983
TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE : 100 ppm/7H SEX/DURATION : female 1-19 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975- Volume(issue)/page/year: 7(Suppl 4),66,1981
TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rabbit DOSE : 15 ppm/7H SEX/DURATION : female 1-24 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issu
其他信息
- Acros Organics:氧化苯乙烯 Styrene oxide, 98%(96-09-3)
- Sigma Aldrich:96-09-3(sigmaaldrich)
- 常规方法:200kg镀锌铁桶装。贮存于阴凉、干燥、通风的库房内，远离火种、热源，防潮、防晒，密封贮存。按一般化学品规定贮运。
- 图谱信息:氧化苯乙烯(96-09-3)核磁图( 13 CNMR) 氧化苯乙烯(96-09-3)红外图谱(IR2) 氧化苯乙烯(96-09-3)红外图谱(IR1) 氧化苯乙烯(96-09-3)Raman光谱 氧化苯乙烯(96-09-3)质谱(MS) 氧化苯乙烯(96-09-3)核磁图( 1 HNMR)
- 下游产品:苯乙醇 --> 苯乙醛
- TCI Shanghai:1,2-环氧苯乙烷 Styrene Oxide,>;98.0%(GC)(96-09-3)
- Alfa Aesar:(±)-氧化苯乙烯,98+% (+/-)-Styrene oxide, 98+%(96-09-3)
- 用途一:用于医药、香料中间体
- MOL 文件:96-09-3.mol
- 外观性质:无色至淡黄色液体，有芳香味。
- 用途二:医药中间体。用于β-苯乙醇的中间体。
- 溶于水,有芳香气味,,水溶性3g/L(20℃)。
- 防护措施:参见环氧乙烷（A 125）。
- 蒸气密度:4.14 (vs air)
- 海关编码:29109000
- 氧化苯乙烯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 E0013 氧化苯乙烯 Styrene Oxide 25ML 80元 2014/06/02 E0013 氧化苯乙烯 Styrene Oxide 500ML 445元 2010/06/21 132800025 氧化苯乙烯 Styrene oxide 98% 2.5 LT 1681元
- 方法一:1.将42g过氧苯甲酸、30g苯乙烯和400ml氯仿混匀，在0℃保持24h。取样检查，应有略过量的过氧苯甲酸存在。用过量的10%氢氧化钠溶液洗涤反应产物除去苯甲酸。然后水洗除碱，经无水硫酸钠干燥，蒸馏收集188-192℃馏分，得氧化苯乙烯24-26g。2.由苯乙烯、溴化钠、硫酸、液体烧碱经卤醇化反应、皂化反应、精馏而得环氧苯乙烷。
- 蒸气压:<;1 mm Hg ( 20 °C)
- MSDS 信息:氧化苯乙烯(96-09-3).msds
- 上游原料:氢氧化钠 --> 硫酸 --> 碳酸钠 --> 三氯甲烷 --> 无水醋酸钠 --> 间氯过氧苯甲酸 --> 苯乙烯 --> 氯酸钠 --> 溴化钠 --> 液体烧碱
京ICP备2020036287号