1,2-Dibromo-3-Chloropropane 1,2-二溴-3-氯丙烷

CAS 96-12-8 MFCD00039365

化学结构图

96-12-8
SMILES: ClCC(Br)CBr

化学属性

Mol. FormulaC3H5Br2Cl
Mol. Weight236
Boiling Point200°C(lit.)
TSCAT
Refractive index1.5510 to 1.5540
Density2.05
Melting Point6 ºC
Solubility0.123 G/100 ML
Flash Point77°C(lit.)

别名和识别编码

Chemical Name1,2-Dibromo-3-Chloropropane
CAS Number96-12-8
Alfabeta NameDIBROMOCHLOROPROPANE 123---,
MDL NumberMFCD00039365
Synonym 3-Chloro-1,2-dibromopropane Nemagon 20 1,2-Dibrom-3-chlorpropan DBCP OS 1897 Nematox 1,2-Dibrom-3-chlor-propan Nemagone 3-氯-1,2-二溴丙烷 NEMAFU RCRA waste number U066 Oxy DBCP Dibromochloropropane {Chemi 1,2-dibromo-3-chloropropane*environmentalstandar C3H5Br2Cl (1,2-dibromo-3-chloro-propane) Propane, 1-chloro-2,3-dibromo- Nematocide Nemagon 1，2-二溴-3-氯丙烷 Fumazone 86 OS 1897(R) Dibromchlorpropan Nemafume Fumazone 86E Fumazone Nemagon Soil Fumigant 1-CHLORO-2 3-DIBROMOPROPANE Nemagon 206 SD 1897 3-CHLORO-1,2-DIBROMOPROPANE 1,2- 1,2-dibromo-3-chloro-propan BBC 12 1,2-dibromo-3-chloropropane (DBCP) Fumagon 1,2-Di 1,2-dibromo-3-chloro-propane NCI-C00500 1,2-Dibroom-3-chloorpropaan 1,2-Dibromo-3-cloro-propano Nemagon 90 Nemagon 20G 1-Chloro-2,3-dibromopropane 1,2-DIBR 二溴氯丙烷;1,2-二溴-3-氯丙烷 Nemazon 1,2-dibromo-3-chloropropane(dbcp)-em Fumazone 86e 1-Chloro-2,3-dibromo Nemanax DBCP(R) Crufomate Nemapaz FUMAZONE NEMAGON(R) Nemaset Nemagon soil fumigant FUMAZONE(R) Propane, 1,2-dibromo-3-chloro- 1,2-DIBROMOPROPYL CHLORIDE 3-CHLORO Nemabrom
PubChem Substance ID87565872
EC Number202-479-3
Beilstein Registry Number1732077
Reaxys-RN1732077
Merck Number3020
Chemical Name Translation1,2-二溴-3-氯丙烷
Wiswesser Line NotationG1YE1E
LabNetwork Molecule IDLN00117046
InChIInChI=1S/C3H5Br2Cl/c4-1-3(5)2-6/h3H,1-2H2
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分类

  • {SNA} Separate Source
  • {uni_hamburg} no charge; 1fragment
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Standards for Personal Care and Cosmetic Products, neats, prohibited substances (EU-REGULATION No 1223/2009)

产品应用

  • 该品为独特的杀线虫剂和杀菌剂。但毒性较强，对老鼠经口试验发现有致癌作用，只限用于特殊场合

相关文献及参考

  • Short: III/20a Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei D ... Cl Author: Chihara, H.; Nakamura, N. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/20a Year: 1988 Keyword: NQR ISBN: 3-540-18161-X ISBN: 978-3-540-18161-3 Internet Resource: DOI:10.1007/b31153 RefComment: IX,677 pages. Hardcover Abstract: Nuclear Quadrupole Resonance Spectroscopy has become a standard method for structural research in molecular and solid state physics as well as for different branches of chemistry. The volumes cover data for more than 8,000 substances in the solid state. Data for free molecules have been published in volumes II/14 and II/15 of the New Series. The tables are arranged according to the atomic number of the elements.
  • Short: III/20b Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei Cl ... Rb Author: Chihara, H.; Nakamura, N. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/20b Year: 1988 Keyword: NQR ISBN: 3-540-18483-X ISBN: 978-3-540-18483-6 Internet Resource: DOI:10.1007/b86664 RefComment: IX,717 pages. Hardcover Abstract: Nuclear Quadrupole Resonance Spectroscopy has become a standard method for structural research in molecular and solid state physics as well as for different branches of chemistry. The volumes cover data for more than 8,000 substances in the solid state. Data for free molecules have been published in volumes II/14 and II/15 of the New Series. The tables are arranged according to the atomic number of the elements.
  • Short: III/38B Title: Refractive Indices of Organic Liquids Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/38B Year: 1996 Keyword: organic compounds; refractive index; liquids ISBN: 3-540-60596-7 ISBN: 978-3-540-60596-6 Internet Resource: DOI:10.1007/b85533 RefComment: VII, 4210 pages, Hardcover Abstract: Volume III/38 Optic

安全信息

Warnings TOXIC
GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H350 May cause cancer 可能致癌
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
  • H340 May cause genetic defects 可能导致遗传性缺陷
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTX8750000
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P308+P313
  • P304+P340+P310
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P302+P350
  • P337+P313
  • P303+P361+P353
  • P403+P233
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P305+P351+P338+P337+P313
  • P301+P310+P330
  • P405 Store locked up. 上锁保管。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P302+P352+P312+P362+P364
Signal word Danger
Hazard Codes T T,F
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S7 Keep container tightly closed 保存在严格密闭容器中；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R45 May cause cancer 可能致癌
  • R46 May cause inheritable genetic damage 可能引起遗传基因损害
  • R60 May impair fertility 可能降低生殖能力
  • R52/53
  • R25 Toxic if swallowed 吞咽有毒
  • R48/20/22
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
UN Number 2872 1230
Packing GroupIII
Storage condition 0-10 密封保存 储存温度2-8℃ 0-10°C Refrigerator
Hazard Class6.1 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 49 gm/kg/47W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-28,1978

TYPE OF TEST            : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 ppm/6H/84W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Endocrine - adrenal cortex tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-206,1982

TYPE OF TEST            : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 ppm/6H/76W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-206,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 240 mg/kg/12W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    19

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURAT

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,545,19

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,5

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 27,287,1983

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 103 ppm/8H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 15,448,1956

TYPE OF TEST

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 100 ppm/3D
REFERENCE :
   HCKHDV Huanjing Kexue.  Environmental Sciences.  (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China)   1976-    Adopted vol.
   no. with Vol. 1, 1980.  Volume(issue)/page/year: 5(5),7,1984

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 35 mg/kg
REFERENCE :
   CBTOE2 Cell Biology and Toxicology.  (Princeton Scientific Pub., Inc., 301
   N. Harrison St., CN 5279, Princeton,

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 5 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 10,49,1989

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Researc

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 nL/plate
REFERENCE :
   STEVA8 Science of the Total Environment.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1972- Volume(issue)/page/year:
   11,223,1979

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 50 mg/kg/5D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 77,71,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   79,54,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 250 mg/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; mea

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 33 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue

{

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 10 ppm/6H
SEX/DURATION            : male 40 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.

其他信息

  • MOL 文件:96-12-8.mol
  • 可燃性危险特性:燃烧产生有毒氯化物和溴化物气体
  • 注意事项:未登记，存在致癌和男性不育的危害被WHO列入Ia级
  • Hazard Note:Toxic
  • 图谱信息:1,2-二溴-3-氯丙烷(96-12-8)核磁图( 1 HNMR) 1,2-二溴-3-氯丙烷(96-12-8)Raman光谱 1,2-二溴-3-氯丙烷(96-12-8)红外图谱(IR1) 1,2-二溴-3-氯丙烷(96-12-8)核磁图( 13 CNMR) 1,2-二溴-3-氯丙烷(96-12-8)质谱(MS)
  • 灭火剂:干粉、泡沫、砂土
  • 急性毒性:口服- 大鼠 LD50: 170 毫克 / 公斤; 口服- 小鼠 LD50: 257 毫克/ 公斤
  • 1,2-二溴-3-氯丙烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0806 1,2-二溴-3-氯丙烷 1,2-Dibromo-3-chloropropane 500G 2240元 2014/06/02 C0806 1,2-二溴-3-氯丙烷 1,2-Dibromo-3-chloropropane 25G 319元 2014/06/02 S0669 1,2-二溴-3-氯丙烷(1mg/ml的甲醇溶液)[用于水分析] 1,2-Dibromo-3-chloropropane (1mg/ml in Methanol) [for Water Analysis] 1ML 240元
  • MSDS 信息:1,2-二溴-3-氯丙烷(96-12-8).msds
  • 挥发性有机化合物(VOCs)单组分标准液
  • 中毒症状:对皮肤、眼睛和呼吸道有刺激作用，吸收后会引起头痛、恶心、呕吐、运动失调、语言含糊不清。肝肾损伤是急性中毒的重要特点，长期接触会引起永久性不育。
  • 刺激数据:皮肤- 兔子 10000 毫克 重度; 眼睛- 兔子 1% 轻度
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 类别:农药
  • TSCA:T
  • 外观性质:琥珀色至棕色液体, 有刺鼻气味。
  • Sigma Aldrich:96-12-8(sigmaaldrich)
  • TCI Shanghai:1,2-二溴-3-氯丙烷(1mg/ml的甲醇溶液)[用于水分析] 1,2-Dibromo-3-chloropropane (1mg/ml in Methanol) [for Water Analysis](96-12-8)
  • 急救治疗:对症治疗。
  • 毒性分级:高毒
  • 用途一:该品为独特的杀线虫剂和杀菌剂。但毒性较强，对老鼠经口试验发现有致癌作用，只限用于特殊场合。
  • 方法一:由3-氯丙烯与溴在常压、10-25℃下加成，反应产物经减压蒸馏提纯。将原药加入乳化剂和二甲苯，在55-60℃乳化半小时，制成80%乳剂。原料消耗定额：3-氯丙烯（92%）310kg/t、液溴600kg/t、乳化剂100kg/t、二甲苯40kg/t。
  • 用途二:该品为独特的杀线虫剂和杀菌剂。但毒性较强，对老鼠经口试验发现有致癌作用，只限用于特殊场合
  • 微溶于水，与油类、二氯丙烷、异丙醇混溶，有刺激臭
  • 上游原料:丙烯酰氯 --> 液溴

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Alkyl 烷基卤代烃
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Pesticides - Pesticides & Metabolites
  7. Fungicides - Pesticides
  8. Others - Fungicides
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. D - Alphabetic
  5. DIA - DIC - D
  1. Analytical & Chromatography 分析化学与色谱
  2. Environmental Endocrine Disruptors

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