Proglumide Sodium 丙谷胺钠
CAS 99247-33-3 MFCD00069301
化学结构图
SMILES: [Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)C1C=CC=CC=1
化学属性
| Mol. Formula | C18H25N2NaO4 |
|---|---|
| Mol. Weight | 356.39 |
别名和识别编码
| Chemical Name | Proglumide Sodium |
|---|---|
| Synonym | 4-Benzoylamino-5-dipropylamino-5-oxopentanoic acid sodium-potassium salt N-Benzoyl-N',N'-dipropyl-DL-isoglutamine sodium-potassium salt Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, monosodium Proglumide sodium salt dl-4-Benzamido-N,N-dipropylglutaramic acid sodium salt |
| MDL Number | MFCD00069301 |
| PubChem Substance ID | 24896533 |
| CAS Number | 99247-33-3 |
| Chemical Name Translation | 丙谷胺钠 |
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分类
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cholecystokinins, Cholecystokinnin - Receptor Antagonists, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuropeptides, P, Peptides and Proteins, Peptides for Cell Biology, Proteins and Derivatives
- {SNA} Cholecystokinins, Cholecystokinnin - Receptor Antagonists, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, 生化试剂, 细胞信号转导和神经科学,
相关文献及参考
- [2]. Iwamoto Y, et al. In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol Jpn. 1984 Feb;19(1):53-8.
- [3]. González-Puga C, et al. Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin. J Pineal Res. 2005 Oct;39(3):243-50.
- [4]. Bunney BS, et al. Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the central nervous system. Ann N Y Acad Sci. 1985;448:345-51.
- [5]. Tariq M, et al. Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. J Pharmacol Exp Ther. 1987 May;241(2):602-7.
- [1
- [1]. Ahmad M, et al. The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus. Oxid Med Cell Longev. 2014;2014:630509.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5886 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression Kidney, Ureter, Bladder - hematuria REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2968 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression Kidney, Ureter, Bladder - hematuria REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6110 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression Kidney, Ureter, Bladder - hematuria REFERENCE : OY
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2811 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression Kidney, Ureter, Bladder - hematuria REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year:
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