Trospium Chloride 曲司氯铵
CAS 10405-02-4 MFCD10405024
化学结构图
SMILES: [Cl-].OC(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]12CCCC1)(c1ccccc1)c1ccccc1
化学属性
| Mol. Weight | 428 |
|---|---|
| Mol. Formula | C25H30ClNO3 |
别名和识别编码
| CAS Number | 10405-02-4 |
|---|---|
| Chemical Name | Trospium Chloride |
| Synonym | Spasmex Sanctura Keptan Azoniaspiro(3-alpha-benziloyloxy-nortropan-8,1'-pyrrolidine)-chloride Spasmo 3 AS Xvii 8-alpha-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride Azoniaspiro Compound XVII Azoniaspiro (1?,3?,5?)-3-[(2-Hydroxy-2,2-diphenylacetyl)oxy]-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium] Chloride 曲司氯胺 Trospium chloride Relaspium |
| EC Number | 233-875-4 |
| InChIKey | RVCSYOQWLPPAOA-QKYUOBHYSA-M |
| Wiswesser Line Notation | T56 A AKTJ GQ A-& AT5KTJ &G |
| Chemical Name Translation | 曲司氯铵 |
| MDL Number | N/A |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Tropine derivative with anticholinergic activity. Antispasmodic; used in treatment of urinary incontinence.
相关文献及参考
- [2]. Eric S Rovner, et al. Trospium chloride in the management of overactive bladder. Drugs. 2004;64(21):2433-46.
- Antweiler, H., et al.: Arzneim.-Forsch., 16, 1581 (1966),
- Lux, G., et al.: Fortschr. Med., 96, 2113 (1978),
- Madersbacher, H., et al.: Br. J. Urol., 75, 452 (1995),
- [1]. David RP Guay. Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence. Ther Clin Risk Manag. 2005 Jun; 1(2): 157–167.
- [1]. David RP Guay. Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence. Ther Clin Risk Manag. 2005 Jun; 1(2): 157–167.
- [2]. Eric S Rovner, et al. Trospium chloride in the management of overactive bladder. Drugs. 2004;64(21):2433-46.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 203 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 97700 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15500 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P301+P312
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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