(1R,3r,5S)-3-(2-hydroxy-2,2-diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ium chloride 曲司氯胺

CAS 10405-02-4 MFCD10405024

化学结构图

10405-02-4
SMILES: [Cl-].OC(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]12CCCC1)(c1ccccc1)c1ccccc1

化学属性

Mol. Weight428
Mol. FormulaC25H30ClNO3

别名和识别编码

CAS Number10405-02-4
Chemical Name(1R,3r,5S)-3-(2-hydroxy-2,2-diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ium chloride
Synonym Spasmex Sanctura Keptan Azoniaspiro(3-alpha-benziloyloxy-nortropan-8,1'-pyrrolidine)-chloride Spasmo 3 AS Xvii 8-alpha-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride Azoniaspiro Compound XVII Azoniaspiro (1?,3?,5?)-3-[(2-Hydroxy-2,2-diphenylacetyl)oxy]-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium] Chloride 曲司氯胺 Trospium chloride Relaspium
EC Number233-875-4
InChIKeyRVCSYOQWLPPAOA-QKYUOBHYSA-M
Wiswesser Line NotationT56 A AKTJ GQ A-& AT5KTJ &G
Chemical Name Translation曲司氯胺
MDL NumberN/A
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Tropine derivative with anticholinergic activity. Antispasmodic; used in treatment of urinary incontinence.

相关文献及参考

  • [2]. Eric S Rovner, et al. Trospium chloride in the management of overactive bladder. Drugs. 2004;64(21):2433-46.
  • Antweiler, H., et al.: Arzneim.-Forsch., 16, 1581 (1966),
  • Lux, G., et al.: Fortschr. Med., 96, 2113 (1978),
  • Madersbacher, H., et al.: Br. J. Urol., 75, 452 (1995),
  • [1]. David RP Guay. Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence. Ther Clin Risk Manag. 2005 Jun; 1(2): 157–167.
  • [1]. David RP Guay. Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence. Ther Clin Risk Manag. 2005 Jun; 1(2): 157–167.
  • [2]. Eric S Rovner, et al. Trospium chloride in the management of overactive bladder. Drugs. 2004;64(21):2433-46.

安全信息

RTECSWH1424000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 203 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 8,199,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 97700 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 8,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15500 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 8,199,1974

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)

GHS Symbol
UN Number 3077
Hazard Codes 9
Signal word Warning
WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P312
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupIII

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. mAChR  (毒蕈碱型乙酰胆碱受体)

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