SU5614 (Z)-5-氯-3-((3,5-二甲基-1H-吡咯-2-基)亚甲基)吲哚啉-2-酮

CAS 1055412-47-9 MFCD155412479

化学结构图

1055412-47-9
SMILES: Cc1cc(C)c(/C=C2\C(=O)Nc3ccc(Cl)cc32)[nH]1

化学属性

Mol. Weight272.73
Mol. FormulaC15H13ClN2O
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

CAS Number1055412-47-9
Chemical NameSU5614
Synonym (3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one SU5614; SU 5614; SU5614.
MDL NumberMFCD08443928
PubChem Substance ID329823735
Chemical Name Translation(Z)-5-氯-3-((3,5-二甲基-1H-吡咯-2-基)亚甲基)吲哚啉-2-酮
FormulaC15H13ClN2O
IUPAC Name(3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
InChIKeyXLBQNZICMYZIQT-GHXNOFRVSA-N
InChIInChI=1S/C15H13ClN2O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,1-2H3,(H,18,19)/b12-7-
Canonical SMILESO=C1NC2=C(C=C(Cl)C=C2)/C1=C/C3=C(C)C=C(C)N3
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分类

  • Inhibitors
  • Heterocycles
  • Pharmaceuticals
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Pfizer Compounds, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, S, Tyrosine Kinase (TK), 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Pfizer compou

产品应用

  • SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21.

相关文献及参考

  • Sun, L., et al.: J. Med. Chem., 41, 2588 (1998),
  • Knowles, P., et al.: J. Biol. Chem., 23, 23 (2006),
  • Rizzi, E., et al.: Bioorg. Med. Chem. Lett., 17, 3962 (2007),

安全信息

WGK Germany3
Risk Statements
  • R53 May cause long-term adverse effects in the aquatic environment 对水生环境有长期的有害作用
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. FLT3
  1. Medical Research Areas
  2. JAK/STAT
  3. STAT

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