N-(2-Methyl-5-((Methylamino)Methyl)Phenyl)-4-((4-Phenylquinazolin-2-Yl)Amino)Benzamide N-(2-甲基-5-((甲氨基)甲基)苯基)-4-((4-苯基喹唑啉-2-基)氨基)苯甲酰胺

CAS 1059734-66-5 MFCD159734665

化学结构图

1059734-66-5
SMILES:

化学属性

Mol. Weight474
Mol. FormulaC30H27N5O

别名和识别编码

Chemical Name TranslationN-(2-甲基-5-((甲氨基)甲基)苯基)-4-((4-苯基喹唑啉-2-基)氨基)苯甲酰胺
Chemical NameN-(2-Methyl-5-((Methylamino)Methyl)Phenyl)-4-((4-Phenylquinazolin-2-Yl)Amino)Benzamide
FormulaC30H27N5O
Synonym BMS833923; BMS-833923; BMS 833923; XL139; XL-139; XL 139.
IUPAC NameN-(2-methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide.
InChIKeyKLRRGBHZCJLIEL-UHFFFAOYSA-N
InChIInChI=1S/C30H27N5O/c1-20-12-13-21(19-31-2)18-27(20)33-29(36)23-14-16-24(17-15-23)32-30-34-26-11-7-6-10-25(26)28(35-30)22-8-4-3-5-9-22/h3-18,31H,19H2,1-2H3,(H,33,36)(H,32,34,35)
Canonical SMILESO=C(NC1=CC(CNC)=CC=C1C)C2=CC=C(NC3=NC(C4=CC=CC=C4)=C5C=CC=CC5=N3)C=C2.
MDL Number
CAS Number1059734-66-5
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产品应用

  • BMS-833923, also known as XL-139, is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Hedgehog/Smoothened

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