N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide N-[3-[[5-氟-2-[[4-(2-甲氧基乙氧基)苯基]氨基]-4-嘧啶基]氨基]苯基]-2-丙烯酰胺

CAS 1202757-89-8 MFCD302757898

化学结构图

1202757-89-8
SMILES: C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCOC)cc3)ncc2F)c1

化学属性

Mol. FormulaC22H22FN5O3
Mol. Weight423.44
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameN-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide
Chemical Name TranslationN-[3-[[5-氟-2-[[4-(2-甲氧基乙氧基)苯基]氨基]-4-嘧啶基]氨基]苯基]-2-丙烯酰胺
Chemicalbook IDCB02655392
FormulaC22H22FN5O3
Synonym CC292; CC-292; CC 292; AVL292; AVL-292; AVL 292; Spebrutinib.
IUPAC NameN-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide
InChIKeyKXBDTLQSDKGAEB-UHFFFAOYSA-N
InChIInChI=1S/C22H22FN5O3/c1-3-20(29)25-16-5-4-6-17(13-16)26-21-19(23)14-24-22(28-21)27-15-7-9-18(10-8-15)31-12-11-30-2/h3-10,13-14H,1,11-12H2,2H3,(H,25,29)(H2,24,26,27,28)
Canonical SMILESC=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(OCCOC)C=C3)=NC=C2F)=C1)=O
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产品应用

  • Spebrutinib, also known as AVL-292 or CC-292, is an orally bioavailable, selective inhibitor of BrutonÂ’s agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. By irreversibly inhibiting BTK, administration of this agent may lead to an inhibition of B cell receptor (BCR) signaling and may inhibit cell proliferation of B-cell malignancies.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. BTK

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