Pimasertib N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺
CAS 1236699-92-5 MFCD336699925
化学结构图
SMILES: O=C(NC[C@H](O)CO)c1ccncc1Nc1ccc(I)cc1F
化学属性
| Mol. Weight | 431.2 |
|---|---|
| Mol. Formula | C15H15FIN3O3 |
| Density | 1.769 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 1236699-92-5 |
|---|---|
| Chemical Name | Pimasertib |
| Synonym | N-[(2S)-2,3-Dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide SAR245509; SAR-245509; SAR 245509; MSC1936369B; AS703026; AS 703026; AS-703026; Pimasertib |
| Chemical Name Translation | N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺 |
| Formula | C15H15FIN3O3 |
| IUPAC Name | (S)-N-(2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)isonicotinamide. |
| InChIKey | VIUAUNHCRHHYNE-JTQLQIEISA-N |
| InChI | InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1 |
| Canonical SMILES | O=C(NC[C@H](O)CO)C1=CC=NC=C1NC2=CC=C(I)C=C2F |
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分类
- Amines
- Aromatics
- Heterocycles
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Pimasertib, also known as AS703026, SAR245509, MSC1936369B, is a n orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor AS703026 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
相关文献及参考
- Billadeau, D., et al.: Cancer Res., 55, 3640 (1995),
- Kolch, W., et al.: Biochem. J., 351, 289 (2000),
- Smith, M., et al.: Leukemia, 17, 274 (2003),
- Adjei, A., et al.: J. Clin. Oncol., 26, 2139 (2008),
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