3-(4-(2-((6-Amino-9-((2R,3R,4S,5S)-5-(Ethylcarbamoyl)-3,4-Dihydroxytetrahydrofuran-2-Yl)-9H-Purin-2-Yl)Amino)Ethyl)Phenyl)Propanoic Acid Hydrochloride 3-(4-(2-((6-氨基-9-((2R,3R,4S,5S)-5-(乙基氨基甲酰基)-3,4-二羟基四氢呋喃-2-基)-9H-嘌呤-2-基)氨基)乙基)苯基)丙酸盐酸盐

CAS 124431-80-7 MFCD24431807

化学结构图

124431-80-7
SMILES: [3H]C([3H])(C1C=CC(CCNC2=NC3=C(N=CN3[C@@H]3O[C@@H]([C@@H](O)[C@H]3O)C(=O)NCC)C(N)=N2)=CC=1)C([3H])([3H])C(O)=O

化学属性

Mol. Weight535.98
Mol. FormulaC23H30ClN7O6

别名和识别编码

CAS Number124431-80-7
Chemical Name3-(4-(2-((6-Amino-9-((2R,3R,4S,5S)-5-(Ethylcarbamoyl)-3,4-Dihydroxytetrahydrofuran-2-Yl)-9H-Purin-2-Yl)Amino)Ethyl)Phenyl)Propanoic Acid Hydrochloride
Synonym CGS 21680 Hydrochloride 4-[2-[[6-Amino-9-(N-ethyl-?-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic Acid Hydrochloride
Chemical Name Translation3-(4-(2-((6-氨基-9-((2R,3R,4S,5S)-5-(乙基氨基甲酰基)-3,4-二羟基四氢呋喃-2-基)-9H-嘌呤-2-基)氨基)乙基)苯基)丙酸盐酸盐
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分类

  • Carbohydrates & Derivatives
  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A selective A2A receptor agonist.

相关文献及参考

  • [2]. Komaki S, et al. Trk and cAMP-dependent survival activity of adenosine A(2A) agonist CGS21680 on rat motoneurons in culture. Neurosci Lett. 2012 Jul 26;522(1):21-4.
  • [3]. Zhang M, et al. Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity. J Neuroimmunol. 2016 Apr 15;293:129-36.
  • [4]. Rosaria Volpini, et al. Adenosine receptor agonists: synthesis and binding affinity of 2-(aryl)alkylthioadenosine derivatives.
  • [5]. Melani A, et al. Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res. 2014 Mar 10;1551:59-72.
  • ########
  • [1]. Bao
  • [1]. Bao R, et al. Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 2016 Sep;38(3):969-75.

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adenosine Receptor  (腺苷受体)

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