Tcn238 试剂TCN238
CAS 125404-04-8 MFCD25404048
化学结构图
SMILES: NC1N=C(C=CN=1)/C=C/C1C=CC=CC=1
化学属性
| Mol. Weight | 197.24 |
|---|---|
| Mol. Formula | C12H11N3 |
别名和识别编码
| CAS Number | 125404-04-8 |
|---|---|
| Chemical Name | Tcn238 |
| Synonym | (E)-4-(2-Phenylethenyl)-2-pyrimidinamine |
| Chemical Name Translation | 试剂TCN238 |
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分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- TCN 238 allosteric modulator of the mGlu4 receptor. TCN 238 may be useful in the treatment of motor dysfunction and in the treatment of Parkinson?s disease. TCN 238 is orally bioavailable.
相关文献及参考
- [2]. Pershina EV, et al. Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain. Life Sci. 2016 May 15;153:50-4.
- East, S.P. et al.: Bioorg. Med. Chem. Lett., 20, 4901 (2010);
- [1]. East SP, et al. An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4901-5.
- [1]. East SP, et al. An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4901-5.
- [2]. Pershina EV, et al. Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain. Life Sci. 2016 May 15;153:50-4.
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