(R)-Cetirizine Dihydrochloride
CAS 130018-77-8 MFCD30018778
化学结构图
SMILES: [2H]C([2H])(N1CCN(CC1)C(C1C=CC=CC=1)C1C=CC(Cl)=CC=1)C([2H])([2H])OCC(O)=O
化学属性
| Mol. Weight | 461.81 |
|---|---|
| Mol. Formula | C21H27Cl3N2O3 |
别名和识别编码
| CAS Number | 130018-77-8 |
|---|---|
| Chemical Name | (R)-Cetirizine Dihydrochloride |
| Synonym | 2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride (-)-Cetirizine Dihydrochloride Levocetirizine Dihydrochloride |
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分类
- Aromatics
- Chiral Reagents
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
相关文献及参考
- De Vos, C., et al.: Ann. Allergy, 59, 278 (1987),
- Fadel, R., et al.: Clin. Allergy, 17, 373 (1987),
- Juhlin, L., et al.: J. Allergy Clin. Immunol., 80, 599 (1987),
- [1]. Lohar P, et al. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33(12):e4672.
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