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分类

• Amines
• Aromatics
• Pharmaceuticals
• Intermediates & Fine Chemicals

产品应用

• Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (ra

相关文献及参考

• [2]. Abraham DJ, et al. Allosteric modifiers of hemoglobin: 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, in whole blood, and in vivo in rats. Biochemistry. 1992 Sep 29;31(38):9141-9.
• [3]. Hou H, et al. The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in mice. Radiat Res. 2007 Aug;168(2):218-25.
• [4]. Hou H, et al. Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study. Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1503-9.
• Abraham, D.J., et al.: Biochemistry, 31, 9141 (1992),
• Kleinberg, L., et al.: J. Clin. Oncol., 17, 2593 (1999),
• Pagel, P.S., et al.: J. Pharmacol. Exp. Ther., 285, 1 (1998),
• [1]. Stea B, et al. Efaproxiral red blood cell