Darifenacin Hydrobromide 氢溴酸达非那新

CAS 133099-07-7 MFCD33099077

化学结构图

133099-07-7
SMILES: Br.NC(=O)C([C@H]1CN(CC1)CCC1=CC2CCOC=2C=C1)(C1C=CC=CC=1)C1C=CC=CC=1

化学属性

Mol. Weight507
Mol. FormulaC28H30N2O2·HBr

别名和识别编码

CAS Number133099-07-7
Chemical NameDarifenacin Hydrobromide
Synonym (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-?-?-diphenyl-3-pyrrolidineacetamide Hydrobromide Enablex Emselex
Chemical Name Translation氢溴酸达非那新
MDL NumberN/A
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Amines
  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Used as a medication to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.

相关文献及参考

  • [2]. Miller DW, et al. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn, 2011, 30(8), 1633-1638.
  • [3]. Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol, 2007, 52(3), 842-847.
  • Beaumont, K.C., et al.: Xenobiotica, 28, 63 (1998),
  • Chapple, C.R., et al.: Expert Opin. Invest. Drugs, 13, 1493 (2004),
  • Haab, F., et al.: Eur. Urol., 45, 420 (2004),
  • [1]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.
  • [1]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.
  • [2]. Miller DW, et al. Evaluation of drug efflux transporter

安全信息

GHS Symbol
UN Number 3077
Hazard Codes 9
WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P312
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupIII

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. mAChR  (毒蕈碱型乙酰胆碱受体)

相关产品推荐