HAC-Y6

CAS 1331959-78-4 MFCD431959784

化学结构图

1331959-78-4
SMILES: COc1cc(Cn2c3ccc(C(C)=O)cc3c3cccnc32)cc(OC)c1OC

化学属性

Mol. Weight390.43
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameHAC-Y6
FormulaC23H22N2O4
Synonym HACY6; HAC-Y6; HAC Y6.
IUPAC Name1-(9-(3,4,5-trimethoxybenzyl)-9H-pyrido[2,3-b]indol-6-yl)ethanone
InChIKeyNYMMDHGEECPYAW-UHFFFAOYSA-N
InChIInChI=1S/C23H22N2O4/c1-14(26)16-7-8-19-18(12-16)17-6-5-9-24-23(17)25(19)13-15-10-20(27-2)22(29-4)21(11-15)28-3/h5-12H,13H2,1-4H3
Canonical SMILESCC(C1=CC2=C(N(CC3=CC(OC)=C(OC)C(OC)=C3)C4=NC=CC=C42)C=C1)=O
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

产品应用

  • HAC-Y6 is a novel and potent microtubule inhitor. HAC-Y60 exhibited potent antitumor activity against human hepatocellular carcinoma (HCC) cells in vitro. Western blot and immunofluorescence experiments showed that HAC-Y6 depolymerized microtubules similarly to the effects of colchicine. HAC-Y6 exhibited its antitumor activity by disrupting microtubule assembly, causing cell cycle arrest and apoptosis through both extrinsic and intrinsic pathways in Hep3B cells. ( Oncol Rep. 2010 Nov;24(5):1169-78. )

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Microtubule

相关产品推荐