CAS 1339928-25-4 MFCD439928254-N-Hydroxy-2-(((2-(6-Methoxypyridin-3-Yl)-4-Morpholinothieno[3,2-D]Pyrimidin-6-Yl)Methyl)(Methyl)Amino)Pyrimidine-5-Carboxamide N-羟基-2-(((2-(6-甲氧基吡啶-3-基)-4-吗啉噻吩并[3,2-d]嘧啶-6-基)甲基)(甲基)氨基)嘧啶-5-甲酰胺 -LabNovo

SMILES: COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ncc(C(=O)NO)cn4)cc3n2)cn1

Chemical Name	N-Hydroxy-2-(((2-(6-Methoxypyridin-3-Yl)-4-Morpholinothieno[3,2-D]Pyrimidin-6-Yl)Methyl)(Methyl)Amino)Pyrimidine-5-Carboxamide
Chemical Name Translation	N-羟基-2-(((2-(6-甲氧基吡啶-3-基)-4-吗啉噻吩并[3,2-d]嘧啶-6-基)甲基)(甲基)氨基)嘧啶-5-甲酰胺
Chemicalbook ID	CB42645120
Formula	C23H24N8O4S
Synonym	CUDC907; CUDC 907; CUDC-907; fimepinostat;
IUPAC Name	N-hydroxy-2-(((2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxamide
InChIKey	JOWXJLIFIIOYMS-UHFFFAOYSA-N
InChI	InChI=1S/C23H24N8O4S/c1-30(23-25-11-15(12-26-23)22(32)29-33)13-16-9-17-19(36-16)21(31-5-7-35-8-6-31)28-20(27-17)14-3-4-18(34-2)24-10-14/h3-4,9-12,33H,5-8,13H2,1-2H3,(H,29,32)
Canonical SMILES	O=C(C1=CN=C(N(CC2=CC3=NC(C4=CC=C(OC)N=C4)=NC(N5CCOCC5)=C3S2)C)N=C1)NO

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CUDC-907, also known as fimepinostat, is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC.

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Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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