DTP348

CAS 1383370-92-0 MFCD483370920

化学结构图

1383370-92-0
SMILES: Cc1ncc([N+](=O)[O-])n1CCNS(N)(=O)=O

化学属性

Mol. Weight249.25
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation
Chemical NameDTP348
FormulaC6H11N5O4S
Synonym DTP348; DTP 348; DTP-348.
IUPAC Name2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethylsulfamide.
InChIKeyAVSMSXHPIYIKIJ-UHFFFAOYSA-N
InChIInChI=1S/C6H11N5O4S/c1-5-8-4-6(11(12)13)10(5)3-2-9-16(7,14)15/h4,9H,2-3H2,1H3,(H2,7,14,15)
Canonical SMILESO=S(NCCN1C([N+]([O-])=O)=CN=C1C)(N)=O
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产品应用

  • DTP348 is an oral dual CAIX inhibitor/ radiosensitizer. DTP 348 is an oral dual drug with two mechanisms of action: (1). carbonic anhydrase IX inhibitor which acidifies the intracellular pH through the sulfamide components; (2). radio sensitizer of hypoxic cells through its 5-nitroimidazole moiety.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Carbonic Anhydrase

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