Levosimendan 左西孟旦

CAS 141505-33-1 MFCD41505331

化学结构图

141505-33-1
SMILES: CC1CC(=O)NN=C1C1C=CC(=CC=1)NN=C(C#N)C#N

化学属性

Mol. Weight280.29
Mol. FormulaC14H12N6O

别名和识别编码

CAS Number141505-33-1
Chemical NameLevosimendan
Synonym [[4-[(4R)-1,4,5,6-Terahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]propanedinitrile (R)-Simendan OR-1259 Simdax
Chemical Name Translation左西孟旦
MDL NumberMFCD00867135
Reaxys-RN6959885
Merck Number5471
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic.

相关文献及参考

  • [2]. Papp, Z., et al., Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol, 2012. 159(2): p. 82-7.
  • [3]. Landoni, G., et al., Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies. Crit Care Med, 2012. 40(2): p. 634-46.
  • Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996),
  • Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995),
  • [1]. Nieminen, M.S., et al., Levosimendan: current data, clinical use and future development. Heart Lung Vessel, 2013. 5(4): p. 227-245.
  • [1]. Nieminen, M.S., et al., Levosimendan: current data, clinical use and future development. Heart Lung Vessel, 2013. 5(4): p. 227-245.
  • [2]. Papp, Z., et al., Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol, 2012. 159(2):

安全信息

Hazard Class6.1
Hazard statements
  • H301+H311+H331
RTECSTY1570210
GHS Symbol
UN Number 3439
Signal word
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310+P330
  • P302+P352+P312+P361+P364
  • P304+P340+P311
  • P305+P351+P338+P337+P313
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupIII

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Phosphodiesterase (PDE)  (磷酸二酯酶)

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