SP-2509 (E)-N'-(1-(5-氯-2-羟基苯基)亚乙基)-3-(吗啉磺酰)苯并酰肼

CAS 1423715-09-6 MFCD523715096

化学结构图

1423715-09-6
SMILES: C/C(=N\NC(=O)c1cccc(S(=O)(=O)N2CCOCC2)c1)c1cc(Cl)ccc1O

化学属性

Mol. Weight437.9
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameSP-2509
FormulaC19H20ClN3O5S
Synonym SP2509; SP 2509; SP-2509.
IUPAC Name(E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide.
InChIKeyNKUDGJUBIVEDTF-FYJGNVAPSA-N
InChIInChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,24H,7-10H2,1H3,(H,22,25)/b21-13+
Canonical SMILESO=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCOCC3)=O)=C2
Chemical Name Translation(E)-N'-(1-(5-氯-2-羟基苯基)亚乙基)-3-(吗啉磺酰)苯并酰肼
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产品应用

  • SP-2509 is a novel histone demethylase LSD1 inhibitor, which showed high actitivity on human AML cells. Treatment with the novel LSD1 antagonist SP2509 attenuated the binding of LSD1 with the corepressor CoREST, increased the permissive H3K4Me3 mark on the target gene promoters, and increased the levels of p21, p27 and CCAAT/enhancer binding protein α in cultured AML cells. In addition, SP2509 treatment or LSD1 shRNA inhibited the colony growth of AML cells.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Epigenetics
  3. Histone Demethylase

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