UNC-2025 反式-4-(2-(丁胺基)-5-(4-((4-甲基哌嗪-1-基)甲基)苯基)-7H-吡咯并[2,3-d]嘧啶-7-基)环己醇
CAS 1429881-91-3 MFCD529881913
化学结构图
SMILES: CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1
化学属性
| Mol. Weight | 476.66 |
|---|---|
| Appearance | White solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 反式-4-(2-(丁胺基)-5-(4-((4-甲基哌嗪-1-基)甲基)苯基)-7H-吡咯并[2,3-d]嘧啶-7-基)环己醇 |
|---|---|
| Chemical Name | UNC-2025 |
| Formula | C28H40N6O |
| Synonym | UNC2025, UNC2025, UNC 2025 |
| IUPAC Name | (1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol |
| InChIKey | MJSHVHLADKXCML-RQNOJGIXSA-N |
| InChI | InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)/t23-,24- |
| Canonical SMILES | O[C@H]1CC[C@H](N2C=C(C3=CC=C(CN4CCN(C)CC4)C=C3)C5=CN=C(NCCCC)N=C52)CC1 |
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产品应用
- UNC-2025 is a novel potent and highly orally bioavailable Mer/FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC-2025 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.
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